Projects / Programmes
Epidemiology, etiopathogenesis, diagnosis and treatment of periodontal diseases
Code |
Science |
Field |
Subfield |
3.02.00 |
Medical sciences |
Stomatology |
|
Code |
Science |
Field |
B730 |
Biomedical sciences |
Odontology, stomatology |
periodontal disease, epidemiology, heart infarct, cytokines, MR imaging, diabetes, lasers
Researchers (8)
Organisations (1)
Abstract
In research project we are planning to evaluate the progression of periodontal disease in 555 citiziens of Ljubljana which were first examined before twenty and the second time before ten years. In epidemiological part of the project we will also evaluate the periodontal conditions in 200 patients who survived miocardial infarction. In these patients the level of inflammatory and immunological mediators and antibodies to specific periodontal pathogenes in sera will be evaluated. Periodontal conditions will be evaluated by CPITN index and standard periodontal clinical parameters. In the field of etiopathogenesis of periodontal disease the role of stress and cytokine TNF-alpha in experimental periodontitis in rats will be studied. In addition, the presence of NO in crevicular fluid and gingiva of diabetic patients with periodontal inflammation will be evaluated. For this part the clinical histological and immunoenzyme methods and tests will be used. The extent of gingival inflammation before and after periodontal therapy in ten patients will be evaluated by magnetic resonance imaging in combination with contrast agent Gd-DTPA. EPR oxymetry in rats will be used to study the role of size and structure of liposomes and nanoparticles for optimal preparation of vehicle for local drug delivery in periodontal treatment. In twenty patients with diabetes type one the role of full-mouth desinfection and local delivery of minocycline on periodontal inflammation and metabolic control of diabetes will be studied. With electron microscopy, EPR and infrared spectroscopy the effect of Er-YAG laser on root surface will be studied. In addition, Er-YAG laser will be clinically evaluated for use in periodontal surgery.