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Projects / Programmes source: ARIS

Treatment of renal anemia with iron and epoetin

Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
B560  Biomedical sciences  Urology, nephrology 
Keywords
anemia, renal failure, iron, epoetin
Evaluation (rules)
source: COBISS
Researchers (10)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  01972  PhD Andrej Bren  Cardiovascular system  Head  2002 - 2004 
2.  10649  PhD Jadranka Buturović-Ponikvar  Cardiovascular system  Researcher  2002 - 2004 
3.  20956  Liljana Gaber    Researcher  2002 - 2004 
4.  01977  PhD Aljoša Kandus  Cardiovascular system  Researcher  2002 - 2004 
5.  20954  Mida Kandus    Researcher  2002 - 2004 
6.  01979  Mira Koselj  Cardiovascular system  Researcher  2001 - 2002 
7.  01982  PhD Radoslav Kveder  Cardiovascular system  Researcher  2002 - 2004 
8.  23258  PhD Jernej Pajek  Cardiovascular system  Researcher  2002 - 2004 
9.  01987  PhD Rafael Ponikvar  Cardiovascular system  Researcher  2002 - 2004 
10.  08767  Janez Varl  Cardiovascular system  Researcher  2002 - 2004 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  125 
Abstract
Correction of renal anemia with iron supplements and epoetin is important in diminishing of morbidity and mortality and improving of life quality in patients with renal failure. Epoetin also abolished or drastically decreased the need for blood transfusions in these patients. Nevertheless, the treatment with epoetin is still expensive and not without side effects, and every effort must be done to optimize such treatment. The objective of our study is to optimize correction of anemia and epoetin dozing in predialysis patients (grup A), in hemodialysis patients (group B), in peritoneal dialysis patients (group C), and in patients with cronic renal graft failure (group D). In group A and group D, we shall try to find out at which degree of renal failure renal anemia appears and should be treated, what is the best way for iron stores replenishment, and at which level epoetin dozing is the most rational. We shall also try to investigate whether the correction of anemia with epoetin has influence on worsening of native and renal graft function. In group B and group C, we shall look for the possible connection between the level of iron stores (higher than subnormal) and epoetin doses in sustaining the same degree of anemia correction. In grup B, the possible benefical influence of low molecular heparin on epoetin consumption in respect to standard heparin will be investigated. Safety and eventually side effects of iron supplementation and epoetin treatment will be followed in all groups.
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