Projects / Programmes
Treatment of renal anemia with iron and epoetin
| Code |
Science |
Field |
Subfield |
| 3.07.00 |
Medical sciences |
Metabolic and hormonal disorders |
|
| Code |
Science |
Field |
| B560 |
Biomedical sciences |
Urology, nephrology |
anemia, renal failure, iron, epoetin
Researchers (10)
Organisations (1)
Abstract
Correction of renal anemia with iron supplements and epoetin is important in diminishing of morbidity and mortality and improving of life quality in patients with renal failure. Epoetin also abolished or drastically decreased the need for blood transfusions in these patients. Nevertheless, the treatment with epoetin is still expensive and not without side effects, and every effort must be done to optimize such treatment. The objective of our study is to optimize correction of anemia and epoetin dozing in predialysis patients (grup A), in hemodialysis patients (group B), in peritoneal dialysis patients (group C), and in patients with cronic renal graft failure (group D). In group A and group D, we shall try to find out at which degree of renal failure renal anemia appears and should be treated, what is the best way for iron stores replenishment, and at which level epoetin dozing is the most rational. We shall also try to investigate whether the correction of anemia with epoetin has influence on worsening of native and renal graft function. In group B and group C, we shall look for the possible connection between the level of iron stores (higher than subnormal) and epoetin doses in sustaining the same degree of anemia correction. In grup B, the possible benefical influence of low molecular heparin on epoetin consumption in respect to standard heparin will be investigated. Safety and eventually side effects of iron supplementation and epoetin treatment will be followed in all groups.
