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Projects / Programmes source: ARIS

Immunomodulation in solid malignant tumors refractory to standard treatment

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Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B200  Biomedical sciences  Cytology, oncology, cancerology 
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
cancer,allogeneic mononuclear cells, dendritic cells, tumour vaccine
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (17)
no. Code Name and surname Research area Role Period No. of publications
1.  07192  PhD Ksaverija Ferlan-Marolt  Oncology  Researcher  2002 - 2004  189 
2.  13188  PhD Rado Janša  Physics  Researcher  2002 - 2004  200 
3.  01302  PhD Matjaž Jeras  Biotechnology  Researcher  2002 - 2004  363 
4.  10038  PhD Miomir Knežević  Biotechnology  Researcher  2002 - 2004  296 
5.  10066  PhD Borut Kocijančič  Medical sciences  Researcher  2002 - 2004  77 
6.  15472  PhD Boštjan Luzar  Oncology  Researcher  2002 - 2004  456 
7.  03171  PhD Aleksandra Markovič-Predan  Medical sciences  Researcher  2002 - 2004  284 
8.  13551  Vladimir Mlinarič  Medical sciences  Researcher  2002 - 2004  40 
9.  10910  PhD Vladislav Pegan  Cardiovascular system  Researcher  2002 - 2004  162 
10.  10909  PhD Alojz Pleskovič  Neurobiology  Researcher  2002 - 2004  197 
11.  19204  Aljaž Repše  Oncology  Researcher  2002 - 2004  15 
12.  01528  PhD Stanislav Repše  Oncology  Researcher  2002 - 2004  308 
13.  12336  PhD Primož Rožman  Microbiology and immunology  Researcher  2002 - 2004  483 
14.  14308  Valentin Sojar  Cardiovascular system  Researcher  2002 - 2004  139 
15.  14484  Dragoje Stanisavljevič  Cardiovascular system  Researcher  2002 - 2004  133 
16.  11949  PhD Borut Štabuc  Oncology  Head  2002 - 2004  677 
17.  10067  MSc Srečko Štepec  Metabolic and hormonal disorders  Researcher  2002 - 2004  89 
Organisations (3)
no. Code Research organisation City Registration number No. of publications
1.  0311  Blood Transfusion Centre of Slovenia  Ljubljana  5053960  1,737 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,480 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,255 
Abstract
In patients with malignant solid tumors refractory to irradiation, chemoterapy and treatment with immunomodulatory agents, the supressed immune response to tumor will be removed and replaced by allogeneic mononuclear cells. Tumor response and survival as well as the effect on patients' immune sistem will be evaluated. Specific anti-tumor cellular and humoral responses induced by deblocking the immune system will be amplified by the use of allogeneic dendritic cells in combination with patient tumor cells. For that purpose cyclophosphamid, anti-lymphocyte T polyclonal and monoclonal antibodies will be applied leading to depletion of lymphocytes T, aiming mostly at activated supressor cells. This treatment will be followed by infusion of allogeneic mononuclear cells with or without dendritic cells in combination with tumor cells to additionally remove supressive barriers and to activate patient's immune system. The concept of this approach is similar to desirable induction of graft versus leukemia effect (GvL) in bone-marrow transplantation. 20 patients will be inclouded. Treatment will be in outpatient and inpatient basis. Duration of treatment will be 42 days.
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