Projects / Programmes
Prognostic factors in early stages of invasive cervical cancer
Code |
Science |
Field |
Subfield |
3.04.00 |
Medical sciences |
Oncology |
|
Code |
Science |
Field |
B570 |
Biomedical sciences |
Obstetrics, gynaecology, andrology, reproduction, sexuality |
early invasive cervical cancer, pathomorphologic criteria, biological markers
Researchers (14)
Organisations (1)
Abstract
The aim of this research is to find and evaluate most of prognostic factors for early invasive cervical cancer in order to decrease the radicality of surgical treatment, thus preserve the patient's reproductive potentials, and to decrease the occurrence of chronic complications following radical surgery. Pathomorphological criteria and expression of biochemical and biological markers will be evaluated in early invasive cervical cancer (FIGO stages Ia, Ib). In the first year 237 stored specimens of microinvasive cancer will be imunohistochemically tested to improve the existing pathomorphological scoring system, which represents the basis for surgical radicality. Prospectively, all patients with early invasive cervical cancer (FIGO stage Ia, Ib) will be enrolled in the study. Blood specimens for the detection of biochemical marker SCC-Ag will be taken and the operated specimens will be evaluated for pathomorphological criteria, scored, and imunohistochemically treated for presence and expression of biologic markers (PCNA,VEGF). Patients will be treated according to the established oncological criteria for cervical cancer with a regular 6-month follow-up. In the last year of the project less radical surgical procedures will be performed according to preliminary analysis of patomorphological scoring system combined with biochemical and biological markers. Clinical decisions will be evaluated on the results obtained on follow up.