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Projects / Programmes source: ARIS

Prognostic factors in early stages of invasive cervical cancer

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B570  Biomedical sciences  Obstetrics, gynaecology, andrology, reproduction, sexuality 
Keywords
early invasive cervical cancer, pathomorphologic criteria, biological markers
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  08906  PhD Mojca Eržen  Human reproduction  Researcher  2002 - 2004  116 
2.  17635  Klementa Habjan    Researcher  2002 - 2004 
3.  06970  PhD Borut Kobal  Human reproduction  Researcher  2002 - 2004  420 
4.  17638  Meta Kovačič Lužnik    Researcher  2002 - 2004 
5.  19452  Marja Lenart  Human reproduction  Researcher  2002 - 2004  11 
6.  06171  PhD Adolf Lukanovič  Human reproduction  Researcher  2002 - 2004  781 
7.  13515  PhD Leon Meglič  Human reproduction  Researcher  2002 - 2004  151 
8.  06173  Andrej Možina  Human reproduction  Researcher  2002 - 2004  172 
9.  22159  Martina Pečlin    Researcher  2002 - 2004 
10.  14534  Mojca Pirc  Human reproduction  Researcher  2002 - 2004  23 
11.  02355  PhD Stelio Rakar  Human reproduction  Head  2002 - 2004  272 
12.  21362  PhD Špela Smrkolj  Human reproduction  Researcher  2002 - 2004  304 
13.  07183  Jasna Šinkovec  Human reproduction  Researcher  2002 - 2004  134 
14.  17654  Milica Trenkić    Researcher  2001 - 2002 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,764 
Abstract
The aim of this research is to find and evaluate most of prognostic factors for early invasive cervical cancer in order to decrease the radicality of surgical treatment, thus preserve the patient's reproductive potentials, and to decrease the occurrence of chronic complications following radical surgery. Pathomorphological criteria and expression of biochemical and biological markers will be evaluated in early invasive cervical cancer (FIGO stages Ia, Ib). In the first year 237 stored specimens of microinvasive cancer will be imunohistochemically tested to improve the existing pathomorphological scoring system, which represents the basis for surgical radicality. Prospectively, all patients with early invasive cervical cancer (FIGO stage Ia, Ib) will be enrolled in the study. Blood specimens for the detection of biochemical marker SCC-Ag will be taken and the operated specimens will be evaluated for pathomorphological criteria, scored, and imunohistochemically treated for presence and expression of biologic markers (PCNA,VEGF). Patients will be treated according to the established oncological criteria for cervical cancer with a regular 6-month follow-up. In the last year of the project less radical surgical procedures will be performed according to preliminary analysis of patomorphological scoring system combined with biochemical and biological markers. Clinical decisions will be evaluated on the results obtained on follow up.
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