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Projects / Programmes source: ARIS

Genetic and environmental risk factors for bone remodelation disturbances

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Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
B580  Biomedical sciences  Skeleton, muscle system, rheumatology locomotion 
Keywords
osteoporosis, estrogen receptor, tartrate resistant acinaphosphatase, bone alkaline phosphatase
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publications
1.  20373  PhD Darja Bitenc Logar  Pharmacy  Researcher  2002 - 2004  17 
2.  19785  PhD Bojan Doljak  Pharmacy  Researcher  2002 - 2004  257 
3.  21692  Irena Klančnik Mavec    Researcher  2002 - 2004  0 
4.  15460  PhD Samo Kreft  Pharmacy  Head  2002 - 2004  779 
5.  03573  PhD Jana Lukač Bajalo  Microbiology and immunology  Researcher  2002 - 2004  302 
6.  12189  PhD Janja Marc  Metabolic and hormonal disorders  Researcher  2002 - 2004  712 
7.  18154  PhD Barbara Ostanek  Metabolic and hormonal disorders  Researcher  2002 - 2004  188 
8.  19786  Majda Sirnik    Researcher  2002 - 2004  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,159 
Abstract
Osteoporosis is a multifactorial bone disease influenced by genetic an environmental factors (physical activity, diet). The connection between decreased bone mineral density (main symptom of the osteoporosis) and the treatment effect on one hand and the presence of genetic modifications (mutations) in the genes for estrogenic receptor alpha and beta and gene for cathepsin K will be studied. For this purpose, the coding regions of the three genes will be examined for the presence of genetic modifications, and protocols for their routine determination in patients will be developed.Medicinal plants and plant derived food will be screened for the presence of inhibitors of two enzymes: 1) bone alkaline phosphatase, which is involved in bone formation and 2) tartrat resistant acid phosphatase, which is involved in bone resorption. The inhibitors of the first enzyme could accelerate the osteoporosis process and people from the risk groups should avoid such food. The inhibitors of the second enzyme could be slow down the disease process and could lead to the development of new drugs against osteoporosis.
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