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Projects / Programmes source: ARIS

Keratin cytoskeleton dynamics and disease phenotype development

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Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
B220  Biomedical sciences  Genetics, cytogenetics 
B210  Biomedical sciences  Histology, cytochemistry, histochemistry, tissue culture 
B630  Biomedical sciences  Dermatology, venereology 
Keywords
EBS, mutations, keratin, intermediate filaments, cytoskeleton, GFP, microscopy
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (4)
no. Code Name and surname Research area Role Period No. of publications
1.  21039  PhD Mojca Gabrovšek  Biochemistry and molecular biology  Researcher  2002 - 2004  8 
2.  18529  Dubravka Germ    Researcher  2002 - 2004  0 
3.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  2002 - 2004  1,054 
4.  14305  PhD Mirjana Liović  Metabolic and hormonal disorders  Head  2002 - 2004  147 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,203 
Abstract
Although much is known about the molecular defects underlying human hereditary skin disorders caused by keratin intermediate filament deficiency, little progress has been made in defining the mechanism(s) of disease phenotype development. The goal of this project is to study the cytoskeleton dynamics of healthy epithelial cell lines grown in tissue culture, and to use this information to identify the processes giving rise to the pathological phenotype in mutants, i.e. cells that express mutated keratins. For this purpose epidermolysis bullosa simplex (EBS) and keratins 5 and 14 (K5/K14) were chosen as a model system, as EBS is one of the best documented hereditary skin disorders.
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