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Projects / Programmes
Calcium and cAMP “in vivo” and their influence on intracellular pH in Aspergillus niger
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 4.06.00 | Biotechnical sciences | Biotechnology |
| Code | Science | Field |
|---|---|---|
| T490 | Technological sciences | Biotechnology |
| T360 | Technological sciences | Biochemical technology |
| B230 | Biomedical sciences | Microbiology, bacteriology, virology, mycology |
| B220 | Biomedical sciences | Genetics, cytogenetics |
Keywords
cAMP, calcium, signal transduction, fungi, Aspergillus niger, intracellular pH
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (1) , Researchers (3)
0104 National Institute of Chemistry
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 14360 | Biotechnology | Head | 2002 - 2004 | 411 | |
| 2. | 00385 | Biotechnology | Researcher | 2002 - 2004 | 227 | |
| 3. | 17028 | Law | Researcher | 2001 - 2002 | 285 |
Abstract
In biotechnologically important fungus Aspergillus niger, plasma membrane H+-ATPase plays a significant role in controlling intracellular pH and global regulation of metabolism. The activity of H+-ATPase is regulated by calcium/calmodulin-dependent protein kinase phosphorylation. After cloning and characterisation of calcium/calmodulin-dependent protein kinase, its involvement in signal transduction will be determined. Cyclic-AMP and phospholipid signal transduction cross talk will be determined using a novel recombinant system for detection of cytosolic free calcium ions and cAMP "in vivo" in A. niger.