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Projects / Programmes source: ARIS

EARLY DETECTION OF LUNG CANCER AND RISK FACTORS FOR DEVELOPMENT AND PROGRESS OF DISEASE

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B520  Biomedical sciences  General pathology, pathological anatomy 
Keywords
LUNG CANCER, SPECTRAL ANALYSIS, FLUORESCENCE ENDOSCOPY, QUANTITATIVE PATHOLOGY
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  19651  PhD Andreja Aleš Rigler  Microbiology and immunology  Researcher  2003 - 2005  153 
2.  08827  MSc Marko Bitenc  Oncology  Researcher  2003 - 2005  140 
3.  02005  PhD Janez Eržen  Oncology  Researcher  2003 - 2005  188 
4.  16048  PhD Igor Fajdiga  Oncology  Researcher  2003 - 2005  113 
5.  11154  MSc Barbara Salobir  Cardiovascular system  Researcher  2003 - 2005  59 
6.  09763  PhD Mihael Sok  Oncology  Researcher  2003 - 2005  221 
7.  08094  PhD Mirza Šabovič  Cardiovascular system  Researcher  2003 - 2005  424 
8.  06661  PhD Marjeta Terčelj Zorman  Microbiology and immunology  Head  2003 - 2005  414 
9.  15779  MSc Matjaž Turel  Microbiology and immunology  Researcher  2003 - 2005  165 
10.  07750  PhD Matjaž Zwitter  Oncology  Researcher  2003 - 2005  386 
11.  02132  PhD Miha Žargi  Oncology  Researcher  2003 - 2005  392 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,793 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,959 
Abstract
his research proposal is testing the hypothesis postulating that the new fluorescence endoscopy technology, combined with simultaneous spectral analysis will increase sensitivity of detecting of very early carcinoma, carcinoma in situ (CIS) and dysplastic lesions and early metastases in endobronchial mucosa while at the same significantly increasing fluorescence endoscopy specificity. The current fluorescence systems have increased sensitivity of the early lung cancers (e.g. from 25% to 90% for CIS) but at the expense of specificity (a drop from 90% to 60 - 66 %) resulting in a large number of unnecessary biopsies in a single bronchoscopy session. The biopsies will be analysed both by conventional and quantitative pathology to reduce subjective classifications of the early lesions. Patients with malignancy in oropharingeal area often develop primary malignancy in the lung. Therefore, in our project we are going to test our hypothesis starting that we could detect very early lung cancer in such patients with spectral endoscopy. For this reason we will include such patients in the study. At the same time we shall test for the presence of selected viral infectious that are believed to be responsible for rapid progression of malignancy. We shall measure the impact of the fibrinolytic enzyme system on prognosis and survival of lung cancer patients. The combined program should result in a better management of lung cancer patients including reduced mortality, longer survival, better quality of life and increased cost-effectiveness of treatment.
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