Projects / Programmes
THE INFLUENCE OF RATIONAL ANTIMICROBIAL TREATMENT ON CLINICAL OUTCOME AND BACTERIAL RESISTANCE IN GENERAL HOSPITAL
| Code |
Science |
Field |
Subfield |
| 3.01.00 |
Medical sciences |
Microbiology and immunology |
|
| Code |
Science |
Field |
| B510 |
Biomedical sciences |
Infections |
antibiotics, drug utilizsation, hospitals, hospitalization, resistance microbial, bacteria-isolation and purification, pharmaco-economy
Researchers (9)
Organisations (1)
| no. |
Code |
Research organisation |
City |
Registration number |
No. of publicationsNo. of publications |
| 1. |
1187 |
General hospital Celje |
Celje |
5064716 |
2,846 |
Abstract
Antimicrobials are among most commonly prescribed drugs in hospitals. In an era of growing concern about bacterial resistance and hospital costs, limiting the use of antimicrobials is important.
We wish to evaluate the effects of rational use of antimicrobials on expenditures, antimicrobial resistance rates and clinical outcomes of hospitalised patients.
Convincing evidence indicates that bacterial resistance to antibiotics result primarily from the selective pressure exerted by the use and overuse of antimicrobial agents. Some institutions have shown that antimicrobial restriction policies, although unpopular, are temporally associated with reversion of bacterial resistance. The extent and velocity to which these programs can influence resistance patterns of many nosocomial bacteria are, however, unknown and will be investigated in our study.
The study is based on a collaborative, multidisciplinary approach toward promotion of the optimal cost-effective utilisation of antimicrobials and its influence on clinical outcome and on bacterial resistance.
Techniques of rational antimicrobial therapy include the use of antimicrobial order sheets, automatic stop orders, antibiotic restriction systems, ongoing drug-use evaluation and review, and administrative interventions such as usage/practice guidelines.
Trends of antimicrobial resistance will be followed by comparing the rates of resistance of the most frequent nosocomial bacteria. For all isolates the susceptibility to different antimicrobials will be determined by disk diffusion technique. After eliminating duplicate isolates, data will be tabulated by bacterial species and by patient hospitalisation area and will be analysed using statistical software package.
We expect that restricted use of selected antimicrobials will be associated with important hospital monetary savings and improvements in bacterial susceptibility rates without compromising patient outcome. In an era of growing concern about emerging microorganisms resistant to multiple antimicrobials, with the potential for their intercontinental spread, it is crucial that all hospitals worldwide implement policies to control antimicrobial utilisation.
