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Projects / Programmes source: ARIS

Influences on immune parameters in patients with schizophrenia

Research activity

Code Science Field Subfield
3.09.00  Medical sciences  Psychiatry   

Code Science Field
B650  Biomedical sciences  Psychiatry, clinical psychology, psychosomatics 
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
schizophrenia, course of illness, treatment, immune system
Evaluation (rules)
source: COBISS
Researchers (3)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  20256  PhD Bojana Avguštin  Psychiatry  Junior researcher  2003 - 2005  68 
2.  12479  PhD Virginija Novak Grubič  Psychiatry  Researcher  2003 - 2005  84 
3.  13382  PhD Rok Tavčar  Psychiatry  Head  2003 - 2005  283 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  1620  University Psyhiatric Hospital  Ljubljana - Polje  1191004000  3,485 
Abstract
The etiology of schizophrenia is not yet known. Immune mechanism has been established as one of possible etiological factors in schizophrenia. In several studies the dysfunctions of the immune system in subgroups of patients with schizophrenia have been described. It seems that a TH1-TH2 imbalance with a shift to the TH2 response is present in a subgroup of patients with predominantly negative symptoms and poor therapeutic response to antipsychotics. The aim of our study is to establish the relationships between immunological alterations and some clinical, demographic, therapeutic and prognostic variables in patients with schizophrenia. Patients with different subtypes of schizophrenia will be studied in separate groups, determined with standarized clinical scales. Cytokine measurements will be performed with sensitive and standarized immunological methods. We will compare two different assay of cytokine measurements (flow cytometry and enzyme-linked immunosorbent assay).
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