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Projects / Programmes source: ARIS

The influence alpha 2 adrenergic receptor agonists and cyclooxygenase 2 inhibitors on the immune, neuroendocrine and inflammatory response in the perioperative perioed and early postoperative complications during major surgical procedures

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Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   
Keywords
stress response, alpha2-adrenoceptor agonist, clonidine, epidural anaesthesia, cyclooxygenase 2 inhibitors, inflammation
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publications
1.  02086  PhD Aleksander Manohin  Metabolic and hormonal disorders  Researcher  2003 - 2004  156 
2.  14939  PhD Vesna Novak Jankovič  Neurobiology  Head  2003 - 2004  319 
3.  10691  PhD Joško Osredkar  Human reproduction  Researcher  2003 - 2004  1,318 
4.  02259  PhD Vesna Paver-Eržen    Researcher  2003 - 2004  154 
5.  14375  MSc Neva Požar - Lukanovič    Researcher  2003 - 2004  131 
6.  09763  PhD Mihael Sok  Oncology  Researcher  2003 - 2004  221 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  78,445 
Abstract
In the prospective double-blind randomised study the effects of epidural clonidine and cyclooxygenase 2 inhibitors and their influence on the immune, neuroendocrine and inflammatory stress response during major surgical procedures will be studied. White cell blood count, lymphocytes and NK cells will be followed during the surgical procedures and three days postoperatively. The concentrations of proinflammatory cytokines IL-1, IL-6 and TNF-alpha will be studied during surgical procedures and three days postoperatively. Increased amount of purulent expectorate, increased body temperature and radiologic evidence of new lung infiltration will be investigated.
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