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Projects / Programmes source: ARIS

SOME GENETIC FACTORS IN THE DEVELOPMENT OF URINARY TRACT MALFORMATIONS AND HYPERTENSION IN CHILDREN

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B790  Biomedical sciences  Clinical genetics 
Keywords
Genetics, urinary tract, malformations, hypertension, preeclampsia, children
Evaluation (rules)
source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  17030  PhD Klementina Fukne-Kokot  Chemical engineering  Researcher  2003 - 2005  25 
2.  03299  PhD Alojz Gregorič  Human reproduction  Head  2003 - 2005  358 
3.  13343  PhD Nadja Kokalj Vokač  Oncology  Researcher  2003 - 2005  450 
4.  15712  Martina Kos  Public health (occupational safety)  Researcher  2005  40 
5.  15998  PhD Nataša Marčun Varda  Cardiovascular system  Researcher  2003 - 2005  477 
6.  21862  Dušanka Meglič  Medical sciences  Researcher  2003 - 2005  54 
7.  21865  Rebeka Vidovič    Technical associate  2003 - 2005 
8.  18205  PhD Boris Zagradišnik  Oncology  Junior researcher  2003 - 2005  259 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,150 
Abstract
The research project in divided in three parts. In the first part of the project (Analysis of some genetic factors in the development of renal and urinary tract malformations) we are going to investigate families (100) with renal and urinary tract malformations nad by the help of genetic analysis detect the genes involved. By means of the linkage disequilibrium method we intend to find the connection between genome regions with possible key genes and specific phenotypes of renal and urinary tract malformations. The aim of our study is to confirm or disprave with mutation analysis the role of gene in development of renal and urinary tract malformations. The results of the experimental group will be compared with the control group. In the second part of our project (The role of some genetic factors in the development of essential hypertension) we intend to genetically investigate 100 families, in wich at least one child has essential hypertension. The mentioned linkage disequilibrium method will be used and some genes involved in the etiopathogenesis of essential hypertension are tried to be detected. The aim of the study in also to find some differences between the experimental and control group regarding the target organ lesion and arterial stiffnes analysis. The third part of our project (Genetic disposition for essential hypertension in children whose mothers had preeclampsia) is based on studies in wich the connection of the angiotensinogen gene M235T polymorphism with essential and also preeclamptic hypertension was established. Regarding the discovered connection of the angiotensinogen gene M235T polymorphism with both mentioned forms of hypertension is the aim of our research to determine by the help of this genetic polymorphism (using also the control groups) wheter there is a genetic disposition for essential hypertension in those children (50), whose mother (50) had preeclampsia during their pregnancy. To best of our knowledge such like research has not been previously published.
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