Projects / Programmes
SOME GENETIC FACTORS IN THE DEVELOPMENT OF URINARY TRACT MALFORMATIONS AND HYPERTENSION IN CHILDREN
Code |
Science |
Field |
Subfield |
3.05.00 |
Medical sciences |
Human reproduction |
|
Code |
Science |
Field |
B790 |
Biomedical sciences |
Clinical genetics |
Genetics, urinary tract, malformations, hypertension, preeclampsia, children
Researchers (8)
Organisations (1)
Abstract
The research project in divided in three parts. In the first part of the project (Analysis of some genetic factors in the development of renal and urinary tract malformations) we are going to investigate families (100) with renal and urinary tract malformations nad by the help of genetic analysis detect the genes involved. By means of the linkage disequilibrium method we intend to find the connection between genome regions with possible key genes and specific phenotypes of renal and urinary tract malformations. The aim of our study is to confirm or disprave with mutation analysis the role of gene in development of renal and urinary tract malformations. The results of the experimental group will be compared with the control group.
In the second part of our project (The role of some genetic factors in the development of essential hypertension) we intend to genetically investigate 100 families, in wich at least one child has essential hypertension. The mentioned linkage disequilibrium method will be used and some genes involved in the etiopathogenesis of essential hypertension are tried to be detected. The aim of the study in also to find some differences between the experimental and control group regarding the target organ lesion and arterial stiffnes analysis.
The third part of our project (Genetic disposition for essential hypertension in children whose mothers had preeclampsia) is based on studies in wich the connection of the angiotensinogen gene M235T polymorphism with essential and also preeclamptic hypertension was established. Regarding the discovered connection of the angiotensinogen gene M235T polymorphism with both mentioned forms of hypertension is the aim of our research to determine by the help of this genetic polymorphism (using also the control groups) wheter there is a genetic disposition for essential hypertension in those children (50), whose mother (50) had preeclampsia during their pregnancy. To best of our knowledge such like research has not been previously published.