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Projects / Programmes source: ARIS

Pathology and Molecular Genetics

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   
3.04.00  Medical sciences  Oncology   
Evaluation (rules)
source: COBISS
Researchers (55)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  17954  Mojca Bekanovič    Researcher  2004 
2.  24608  PhD Gašper Berginc  Microbiology and immunology  Junior researcher  2005 - 2008  21 
3.  25441  PhD Emanuela Boštjančič  Microbiology and immunology  Junior researcher  2005 - 2008  113 
4.  17952  Tomo Brezovar    Technical associate  2004 - 2006 
5.  05367  PhD Anton Cerar  Oncology  Researcher  2004 - 2008  194 
6.  28344  PhD Katarina Dimnik  Oncology  Junior researcher  2008  33 
7.  17953  Magdalena Dimnik    Technical associate  2004 - 2008 
8.  06207  Zvezdana Dolenc-Stražar  Microbiology and immunology  Technical associate  2004 - 2008  77 
9.  29674  Andreja Drofenik    Technical associate  2008 
10.  07192  PhD Ksaverija Ferlan-Marolt  Oncology  Researcher  2004 - 2008  189 
11.  02273  PhD Dušan Ferluga  Microbiology and immunology  Head  2004 - 2008  531 
12.  07479  PhD Janez Fischinger  Oncology  Researcher  2004  86 
13.  02127  PhD Nina Gale  Oncology  Researcher  2004 - 2008  402 
14.  09275  PhD Damjan Glavač  Chemistry  Researcher  2004 - 2008  561 
15.  17945  Branka Grmek    Technical associate  2004 - 2007 
16.  26059  Katarina Hafner    Technical associate  2008 
17.  27607  PhD Sonja Hrašovec  Biochemistry and molecular biology  Junior researcher  2006 - 2008  12 
18.  07190  PhD Anastazija Hvala  Microbiology and immunology  Researcher  2004 - 2008  172 
19.  17955  Sonja Ivanič    Technical associate  2004 - 2008 
20.  17946  Metka Janc    Technical associate  2004 - 2007 
21.  20201  PhD Maja Jerše  Oncology  Technical associate  2004 - 2008  50 
22.  19130  PhD Jera Jeruc  Microbiology and immunology  Technical associate  2005 - 2008  163 
23.  17948  Alenka Jurančič    Technical associate  2004 - 2005 
24.  11204  PhD Vesna Jurčić  Microbiology and immunology  Researcher  2004 - 2008  149 
25.  24236  Višnja kastelic    Technical associate  2005 
26.  17949  Tadeja Klemenc    Technical associate  2004 - 2008 
27.  02051  Tatjana Kobenter  Microbiology and immunology  Technical associate  2004 - 2008  20 
28.  22462  PhD Nika Kojc  Oncology  Junior researcher  2005 - 2008  185 
29.  21507  PhD Branka Korošec  Systems and cybernetics  Junior researcher  2004 - 2005  61 
30.  15472  PhD Boštjan Luzar  Oncology  Researcher  2004 - 2008  455 
31.  07187  PhD Andrej Mašera  Oncology  Researcher  2004 - 2006  131 
32.  25809  PhD Vid Mlakar  Metabolic and hormonal disorders  Junior researcher  2005 - 2008  96 
33.  17965  Breda Nagode    Technical associate  2004 - 2008  14 
34.  07228  PhD Zdenka Ovčak  Oncology  Researcher  2004 - 2008  78 
35.  02748  Tatjana Perković  Microbiology and immunology  Technical associate  2004 - 2005  58 
36.  23082  PhD Martina Perše  Oncology  Technical associate  2006 - 2008  203 
37.  26058  PhD Jože Pižem  Oncology  Technical associate  2005 - 2008  169 
38.  17950  Majda Prebil    Technical associate  2004 - 2005 
39.  01502  PhD Metka Ravnik-Glavač  Biochemistry and molecular biology  Researcher  2004 - 2008  268 
40.  07184  PhD Tomaž Rott  Microbiology and immunology  Researcher  2004 - 2008  351 
41.  22590  PhD Sava Smerkolj  Biochemistry and molecular biology  Researcher  2004  14 
42.  19141  PhD Irena Srebotnik Kirbiš  Oncology  Technical associate  2007 - 2008  92 
43.  23585  PhD Mojca Stražišar  Oncology  Junior researcher  2004 - 2008  37 
44.  14669  PhD Margareta Strojan Fležar  Oncology  Researcher  2007 - 2008  262 
45.  17947  Nataša Štok-Pfajfar    Technical associate  2004 - 2007 
46.  28142  Urška Teraš    Technical associate  2006 
47.  06661  PhD Marjeta Terčelj Zorman  Microbiology and immunology  Researcher  2004  413 
48.  18362  Daniel Velkavrh    Technical associate  2004 - 2008 
49.  24235  Irena Vidovič    Technical associate  2005 - 2008 
50.  07182  PhD Alenka Vizjak  Microbiology and immunology  Researcher  2004 - 2008  377 
51.  12956  PhD Metka Volavšek  Oncology  Researcher  2004 - 2008  238 
52.  12955  PhD Nina Zidar  Microbiology and immunology  Researcher  2004 - 2008  380 
53.  28143  PhD Andrej Zupan  Oncology  Technical associate  2006 - 2008  53 
54.  29675  Marija Zupančič    Technical associate  2008 
55.  04651  MSc Teofil Žižek  Chemistry  Technical associate  2004 - 2005  14 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  47,522 
Significance for science
Important and internationally recognized achievements of our research team contributed to the understanding of immune mechanisms of tissue injury and inflammation in the kidney and vasculature in different diseases. The members of the team presented their original achievements in the papers published in prestigious journals, cited by the SCI. In one of the largest studies of 358 patients, we demonstrated the relationship between the distribution and the intensity of the glomerular sudendothelial deposits on one side and forms of active lupus nephritis on the other side. Our studies on isolated glomeruli drew attention to the significance of apoptosis and activation of the proinflammatory genes in the pathogenesis of lupus nephritis. They also confirmed the significant role of apoptosis in the early myocardial infarction. We proposed the hypothesis that the absence of the inflammatory changes in the renal arterioles and arteries in comparison with glomeruli might be attributed to the non-fenestrated endothelial cells in these vessels preventing direct contact of immune deposits with the plasma proteins, from which by activation inflammatory mediators are released. The largest study of the clinico-pathologic correlation in C1q nephropathy published so far showed the pathogenetic heterogeneity of the disease. The disease can namely manifest clinically and histopathologically as immune complex glomerulonephritis and vasculitis, resp., or as a noninflammatory podocytopathy presented with nephrotic syndrome and minimal changes or focal segmental glomerulosclerosis. In the study of hantavirus nephropathy, our electron microscopical analysis confirmed that the small vessels of the outer kidney medulla are the main target. It appears that the endotheliotropic hantaviruses are not cytopathogenic and vascular injury results from the interaction of numerous cytokines released during the infection. Significant is also our contribution in the international research group, which elaborated detailed diagnostic criteria for still enigmatic Balkan endemic nephropathy. The international recognition of the original standpoints on classification of precancerous lesions of the larynx and oral cavity (the Ljubljana classification) has been a major success for our research team. Additional criteria for histological evaluation of these lesions were based on immunohistochemical and molecular-genetic analyses (telomerase reactivation, stromal changes and the role of survivin and FHIT gene in the process of squamous cell carcinoma development, and new insights of the apoptosis) as well as on a 25-year follow-up study of patients at different stages of squamous intraepithelial lesions with malignant alteration of 1.1% of cases with the low-risk lesions and of 9.5% of the high risk lesions. Our results have become internationally recognized and the members of our research group were invited authors of some chapters of five scientific books on the head and neck tumors. Our research work, therefore, significantly contributed to reveal new mechanisms in the development of squamous intraepithelial lesions in the head and neck region, as well as to new diagnostic and prognostic factors. In our molecular genetic investigations, we drew attention on some important and unique correlations between genotype and phenotype in several hereditary based syndromes. These data are currently being collected also by The Human Variome Projects, which is the global community's effort to collect, keep and make accessible information on genetic variations affecting human health. Within the research collaboration with The Interdisciplinary Study Group on Gene Environment Interaction and Breast Cancer (GENICA), we found several potential biomarkers for colorectal cancer and breast cancer. A study on breast cancer patients suggested that the TC21 promotor polymorphism was significantly associated with tamoxifen treatment and outcome.
Significance for the country
The introduction of modern technologies, new classifications of renal and vascular diseases, regular clinico-pathological collaborating and the archived research experiences significantly contribute to the higher level of pretentious and complicated biopsy diagnostics. Detailed qualitative and quantitative evaluation of immune and non-immune forms and grades of tissue changes in biopsy samples enables clinicians to make the most appropriate decision for the therapeutic approach and with rebiopsies in the most objective way to follow the effect of therapy and course of the disease. The results of our research of the head and neck carcinogenesis enable earlier diagnostics and more successful treatment of squamous intaepithelial lesions in the head and neck region and thus significantly contribute to improve the state of health of inhabitants of Slovenia, particularly of those with high risk factors (smokers and drinkers). Molecular genetic investigations included some hereditary syndromes as well as cancer, which have not yet been investigated in Slovenian population. We developed an efficient molecular genetic approach for screening of several hereditary diseases in Slovenian population e.g.; multiple endocrine neoplasia MEN-2, Alport syndrome and benign familial hemathuria, Darier disease and Creutzfeld Jakob disease. Furthermore, we showed some important associations with genes in complex diseases such as Chron disease, lung cancer, colorectal cancer and breast cancer. This approach enables us to perform a population screening and identification of novel families with this syndrome that is also associated with early detection and treatment of the disease. We found in hereditary diseases several new and for Slovenian population specific mutations. Through these studies we also developed new methodological approaches for efficient and relatively cost-effective detection of variations in disease genes including capillary electrophoresis-single stranded conformation polymorphism (CE-SSCP), DHPLC methodology and construction of DNA microarray. In additon, our research work importantly influences the under- and postgraduate education of biomedical students and doctors.
Most important scientific results Final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Final report, complete report on dLib.si
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