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Projects / Programmes source: ARIS

Reactive intermediates in the transformation of organic compounds

Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P390  Natural sciences and mathematics  Organic chemistry 
Keywords
oxidation, mechanisms of organic reactions, reactive intermediates, ozone, peroxides, photochemistry
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  25444  PhD Ana Bergant Simončič  Chemistry  Junior researcher  2007 
2.  08385  PhD Janez Cerkovnik  Chemistry  Researcher  2004 - 2007 
3.  08337  PhD Darko Dolenc  Chemistry  Researcher  2004 - 2007 
4.  23493  PhD Maja Harej Perko  Chemistry  Junior researcher  2004 - 2007 
5.  14517  PhD Berta Košmrlj  Chemistry  Researcher  2004 - 2007 
6.  06138  PhD Franci Kovač  Chemistry  Researcher  2004 - 2007 
7.  20458  Branka Miklavčič    Technical associate  2004 - 2007 
8.  06137  PhD Božo Plesničar  Chemistry  Head  2004 - 2007 
9.  06061  PhD Boris Šket  Chemistry  Researcher  2004 - 2007 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  10 
Abstract
(A) Hydrogen trioxide (HOOOH) and alkyl hydrotrioxides (ROOOH) are key intermediates in the low-temperature ozonation of saturated organic substrates and organometallic hydrides, in atmospheric and environmental chemistry, as well as in normal and pathological processes in the living organisms. The proposed project involves studies on the preparation, structure, and reactivity of these interesting compounds and their derivatives (HOOO and ROOO radicals and anions). (B) Employment of photochemically removable protecting groups represents one of the possible methods for a controlled release of bioorganic substrates in vitro. Amongst others the required properties for the successful application of photolabile groups are their good solubility in water and buffer solutions. Our project will be focused on the synthesis of such compounds that can be utilized as photoremovable protecting groups, as well as the study of their photolytic mechanisms. Special attention will be focused to transformations of these compounds to water-soluble form. (C) Our intention is to elucidate the role of the polyvalent halogen radicals in radical abstractions of the halogen (particularly iodine) atoms from organohalogen molecules. Reactivity of these compounds in the abstraction of the iodine atom is strongly influenced by the presence neighboring groups in the molecule. This suggests, along with other features, the existence of the iodanyl (9-I-2) radicals as intermediates.
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