Projects / Programmes
Reactive intermediates in the transformation of organic compounds
| Code |
Science |
Field |
Subfield |
| 1.04.00 |
Natural sciences and mathematics |
Chemistry |
|
| Code |
Science |
Field |
| P390 |
Natural sciences and mathematics |
Organic chemistry |
oxidation, mechanisms of organic reactions, reactive intermediates, ozone, peroxides, photochemistry
Researchers (9)
Organisations (1)
Abstract
(A) Hydrogen trioxide (HOOOH) and alkyl hydrotrioxides (ROOOH) are key intermediates in the low-temperature ozonation of saturated organic substrates and organometallic hydrides, in atmospheric and environmental chemistry, as well as in normal and pathological processes in the living organisms. The proposed project involves studies on the preparation, structure, and reactivity of these interesting compounds and their derivatives (HOOO and ROOO radicals and anions). (B) Employment of photochemically removable protecting groups represents one of the possible methods for a controlled release of bioorganic substrates in vitro. Amongst others the required properties for the successful application of photolabile groups are their good solubility in water and buffer solutions. Our project will be focused on the synthesis of such compounds that can be utilized as photoremovable protecting groups, as well as the study of their photolytic mechanisms. Special attention will be focused to transformations of these compounds to water-soluble form. (C) Our intention is to elucidate the role of the polyvalent halogen radicals in radical abstractions of the halogen (particularly iodine) atoms from organohalogen molecules. Reactivity of these compounds in the abstraction of the iodine atom is strongly influenced by the presence neighboring groups in the molecule. This suggests, along with other features, the existence of the iodanyl (9-I-2) radicals as intermediates.
