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Projects / Programmes source: ARIS

Synthesis of heterocyclic analogs of amino acids and peptides

Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P003  Natural sciences and mathematics  Chemistry 
P390  Natural sciences and mathematics  Organic chemistry 
P395  Natural sciences and mathematics  Organometallic chemistry 
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  23491  PhD David Bevk  Pharmacy  Junior researcher  2004 - 2007  83 
2.  19281  PhD Zdenko Časar  Chemistry  Researcher  2004  166 
3.  22602  PhD Uroš Grošelj  Chemistry  Researcher  2004 - 2007  456 
4.  17140  Tončka Kozamernik-Hudeček    Technical associate  2004 - 2007 
5.  20062  PhD Renata Osolnik  Chemistry  Researcher  2005 - 2007  68 
6.  26549  PhD Lidija Pezdirc  Chemistry  Junior researcher  2006 - 2007  28 
7.  21341  PhD Samo Pirc  Chemistry  Researcher  2004  38 
8.  18316  PhD Lovro Selič  Chemistry  Researcher  2004 - 2007  79 
9.  00868  PhD Branko Stanovnik  Chemistry  Head  2004 - 2007  1,841 
10.  08284  PhD Jurij Svete  Chemistry  Researcher  2004 - 2007  917 
11.  17142  Tatjana Toporiš Stipanovič    Technical associate  2004 - 2007 
12.  25443  PhD Uroš Uršič  Chemistry  Junior researcher  2005 - 2007  32 
13.  26548  PhD Jernej Wagger  Chemistry  Junior researcher  2006 - 2007  60 
14.  15761  PhD Silvo Zupančič  Pharmacy  Researcher  2004 - 2007  31 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,175 
Abstract
Functionalised heterocyclic compounds containing an amino acid or a peptide structural element represent an important group of organic compounds (peptidomimetics) with potential biological activity. Witihin the frame of the proposed research project, novel reagents and synthetic methodologies for the preparation of heterocyclic analogs of amino acids and peptides, as well as related functionalised heterocyclic compounds, will be developped. The main issues of this research project are: a) development of new general synthetic methodologies and new reagents, which would enable selective preparation of diverse types of peptidomimetics (selectivity and diversity oriented synthesis) b) stereochemical studies directed towards development of stereoselective synthetic methods c) application of new reagents and new synthetic methosdologies in parallel and combinatorial synthesis. Within the frame of the above mentioned general research orientation, the following topics will be studied: a) preparation and synthetic applications of new chiral enaminones in the synthesis of optically active heteroarylalanines and related compounds, synthesis of heterocyclic systems with incorporated amino acid structural element, and synthesis of natural product analogs b) study on reactivity of enaminones towards organometallic reagents followed by applications in the synthesis of dehydroalanines, analogs of aplysinopsins, and related compounds c) study on regio- and stereoselective 1,3-dipolar cycloadditions 3-pyrazolidinone-1-azomethine imines leading to 2-amino-1-oxopyrazolo(1,2-a)pyrazole-7-carboxylates as heterocyclic analogs of dipeptides e) applications of new synthetic methods and new reagents in solid-phase synthesis of functionalised heterocycles.
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