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Projects / Programmes source: ARIS

Role of cysteine proteases in inflammation

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Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
Keywords
cathepsins, caspases, lysosome, processing, polysaccharides, osteoarthritis, rheumatoid arthritis
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (10)
no. Code Name and surname Research area Role Period No. of publications
1.  23573  PhD Dejan Caglič  Biochemistry and molecular biology  Junior researcher  2004 - 2007  53 
2.  18801  PhD Marko Fonović  Biochemistry and molecular biology  Researcher  2004 - 2007  187 
3.  10502  PhD Nataša Kopitar Jerala  Biochemistry and molecular biology  Researcher  2004 - 2007  239 
4.  17110  Louisa Johanna Kroon Žitko    Technical associate  2004 - 2007  22 
5.  19366  PhD Aleš Premzl  Pharmacy  Researcher  2004 - 2007  81 
6.  16411  PhD Jerica Rozman Pungerčar  Biochemistry and molecular biology  Researcher  2004 - 2007  61 
7.  14829  PhD Veronika Stoka  Biochemistry and molecular biology  Researcher  2004 - 2007  237 
8.  05234  Mojca Trstenjak Prebanda  Biochemistry and molecular biology  Technical associate  2004 - 2007  64 
9.  07561  PhD Boris Turk  Biochemistry and molecular biology  Head  2004 - 2007  1,037 
10.  01085  PhD Vito Turk  Biochemistry and molecular biology  Researcher  2004 - 2007  1,490 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,858 
Abstract
The proposed project deals with biochemical studies of inflammation processes and the proteases involved, emphasis being on lysosomal cathepsins and caspases. The activation mechanisms of lysosomal proteases, in particular cathepsins B, S and K, as well as the their potential role in activation of proinflammatory caspases, will be subjects of our investigation. The molecular mechanisms underlying two pathologies, osteoarthritis and rheumatoid arthritis will also be investigated. The proposed research program will contribute to a better understanding of proteolysis and its regulation in normal and pathological conditions.
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