Role of cysteine proteases in inflammation

Code

J1-6488 (C) - included in ARIS records

Head

Period

2/1/2004 - 1/30/2007

Range in 2007

0.14 FTE

Science

Natural sciences and mathematics (9)
Other (1)

Reseacher status

Researcher (8)
Junior expert or technical associate (2)

Education

Doctoral degree (8)
Other (2)

Sex

Woman (5)
Man (5)

Status

Employed at RO and RRD (8)
No data on employment in RO (1)
Retired (1)

No. of publications

10–99 (5)
100–999 (3)
1,000–9,999 (2)

Projects / Programmes source: ARIS

source: ARIS

Role of cysteine proteases in inflammation

Research activity

Code	Science	Field	Subfield
1.05.00	Natural sciences and mathematics	Biochemistry and molecular biology

Code	Science	Field
P004	Natural sciences and mathematics	Biochemistry, Metabolism

Keywords

cathepsins, caspases, lysosome, processing, polysaccharides, osteoarthritis, rheumatoid arthritis

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (10)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	23573	PhD Dejan Caglič	Biochemistry and molecular biology	Junior researcher	2004 - 2007	53
2.	18801	PhD Marko Fonović	Biochemistry and molecular biology	Researcher	2004 - 2007	193
3.	10502	PhD Nataša Kopitar Jerala	Biochemistry and molecular biology	Researcher	2004 - 2007	240
4.	17110	Louisa Johanna Kroon Žitko		Technical associate	2004 - 2007	22
5.	19366	PhD Aleš Premzl	Pharmacy	Researcher	2004 - 2007	81
6.	16411	PhD Jerica Rozman Pungerčar	Biochemistry and molecular biology	Researcher	2004 - 2007	61
7.	14829	PhD Veronika Stoka	Biochemistry and molecular biology	Researcher	2004 - 2007	241
8.	05234	Mojca Trstenjak Prebanda	Biochemistry and molecular biology	Technical associate	2004 - 2007	65
9.	07561	PhD Boris Turk	Biochemistry and molecular biology	Head	2004 - 2007	1,054
10.	01085	PhD Vito Turk	Biochemistry and molecular biology	Researcher	2004 - 2007	1,495

Organisations (1)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0106	Jožef Stefan Institute	Ljubljana	5051606000	91,887

Abstract

The proposed project deals with biochemical studies of inflammation processes and the proteases involved, emphasis being on lysosomal cathepsins and caspases. The activation mechanisms of lysosomal proteases, in particular cathepsins B, S and K, as well as the their potential role in activation of proinflammatory caspases, will be subjects of our investigation. The molecular mechanisms underlying two pathologies, osteoarthritis and rheumatoid arthritis will also be investigated. The proposed research program will contribute to a better understanding of proteolysis and its regulation in normal and pathological conditions.