Molecular bases of interactions between hosts and pathogenic microorganisms

Code

J4-6115 (D) - included in ARIS records

Head

PhD Simon Horvat

Period

2/1/2004 - 1/30/2007

Range in 2007

0.02 FTE and 58 unpaid hours

Science

Natural sciences and mathematics (1)
Biotechnical sciences (13)

Reseacher status

Researcher (14)
Junior expert or technical associate (0)

Education

Doctor's degree (14)

Sex

Woman (6)
Man (8)

Status

Employed at RO and RRD (9)
No data on employment in RO (2)
Retired (2)
Deceased (1)

No. of publications

10–99 (2)
100–999 (11)
1,000–9,999 (1)

Projects / Programmes source: ARIS

source: ARIS

Molecular bases of interactions between hosts and pathogenic microorganisms

Research activity

Code	Science	Field	Subfield
4.02.00	Biotechnical sciences	Animal production

Code	Science	Field
B220	Biomedical sciences	Genetics, cytogenetics

Keywords

Mycoplasma gallisepticum, Mycoplasma synoviae, chicken genome, functional genomics, host-pathogen interaction.

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (14)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	07914	PhD Dušan Benčina	Veterinarian medicine	Researcher	2004 - 2007	223
2.	05098	PhD Peter Dovč	Biotechnology	Researcher	2004 - 2007	936
3.	02977	PhD Franc Habe	Animal production	Researcher	2004	265
4.	08187	PhD Antonija Holcman	Animal production	Researcher	2004 - 2007	401
5.	10412	PhD Simon Horvat	Biotechnical sciences	Head	2004 - 2007	568
6.	09755	PhD Milena Kovač	Animal production	Researcher	2004 - 2007	1,225
7.	16361	PhD Tanja Kunej	Animal production	Researcher	2004 - 2007	932
8.	23413	PhD Miha Lavrič	Biotechnical sciences	Junior researcher	2004 - 2007	30
9.	21397	PhD Helena Motaln	Biochemistry and molecular biology	Researcher	2005 - 2007	208
10.	05008	PhD Mojca Narat	Biotechnology	Researcher	2004 - 2007	690
11.	13006	PhD Nežika Petrič	Animal production	Researcher	2004 - 2007	95
12.	06832	PhD Jurij Pohar	Animal production	Researcher	2004 - 2007	212
13.	11906	PhD Aleš Snoj	Animal production	Researcher	2004 - 2007	221
14.	14933	PhD Dušan Terčič	Animal production	Researcher	2004 - 2007	216

Organisations (1)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0481	University of Ljubljana, Biotechnical Faculty	Ljubljana	1626914	67,303

Abstract

Despite of advances in prevention, diagnosis and treatment of infectious diseases, pathogenic micro organisms remain the most important threat to humans and animals. Recent investigations provided some general data that enable better understanding of host pathogen interactions. A key role in the recognition of pathogen (and its antigens like LPS, lipoproteins, RNA, DNA etc.) play so-called TLR (Toll-Like Receptors) which are present on the surface of cells like macrophages, dendritic cells (DC) and on other cells. TLR (TLR1-TLR9) enable activation of the innate immunity effectors, as well as signals that activate an adaptive immunity. Actually, there are many other proteins which enable the transfer of the signal from TLR to the nuclear factor kappa B (NF-kB), which is responsible for induction of expression of several genes being involved in inflammatory and immune response.In chicken a lower number of TLR (TLR1, TLR2, TLR3) than mammals has been found. In addition, recent search of chicken EST sequences identified genes for proteins with known involvement in the TLR pathway (IRAK4, MAL, MyD88, TRAF6), but did not find homologues of some TLRs, or IRAK1, IRAK2 and IRAK9 as well as other proteins of TLR signalling pathway. So, those novel data enable more targeted investigations of interactions between chicken cells (or tissues) and the selected pathogen.It seems that, generally, chicken TLR2 can recognize lipoproteins which are major but variably expressed antigens in several Mycoplasma spp. It is known that hemagglutinins of MG and MS are lipoproteins but their interactions with chicken cells e.g. macrophages, DC, lymphocytes (B and T) and other cells are not known. Using modern tools of functional genomics (microarrays, RT-PCR, mAbs) we will investigate host pathogen interactions in the chicken model during the MG and MS infection.