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Projects / Programmes source: ARIS

Molecular bases of interactions between hosts and pathogenic microorganisms

Research activity

Code Science Field Subfield
4.02.00  Biotechnical sciences  Animal production   

Code Science Field
B220  Biomedical sciences  Genetics, cytogenetics 
Keywords
Mycoplasma gallisepticum, Mycoplasma synoviae, chicken genome, functional genomics, host-pathogen interaction.
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  07914  PhD Dušan Benčina  Veterinarian medicine  Researcher  2004 - 2007  223 
2.  05098  PhD Peter Dovč  Biotechnology  Researcher  2004 - 2007  935 
3.  02977  PhD Franc Habe  Animal production  Researcher  2004  264 
4.  08187  PhD Antonija Holcman  Animal production  Researcher  2004 - 2007  401 
5.  10412  PhD Simon Horvat  Biotechnical sciences  Head  2004 - 2007  561 
6.  09755  PhD Milena Kovač  Animal production  Researcher  2004 - 2007  1,215 
7.  16361  PhD Tanja Kunej  Animal production  Researcher  2004 - 2007  913 
8.  23413  PhD Miha Lavrič  Biotechnical sciences  Junior researcher  2004 - 2007  29 
9.  21397  PhD Helena Motaln  Biochemistry and molecular biology  Researcher  2005 - 2007  207 
10.  05008  PhD Mojca Narat  Biotechnology  Researcher  2004 - 2007  688 
11.  13006  PhD Nežika Petrič  Animal production  Researcher  2004 - 2007  95 
12.  06832  PhD Jurij Pohar  Animal production  Researcher  2004 - 2007  212 
13.  11906  PhD Aleš Snoj  Animal production  Researcher  2004 - 2007  219 
14.  14933  PhD Dušan Terčič  Animal production  Researcher  2004 - 2007  211 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,279 
Abstract
Despite of advances in prevention, diagnosis and treatment of infectious diseases, pathogenic micro organisms remain the most important threat to humans and animals. Recent investigations provided some general data that enable better understanding of host pathogen interactions. A key role in the recognition of pathogen (and its antigens like LPS, lipoproteins, RNA, DNA etc.) play so-called TLR (Toll-Like Receptors) which are present on the surface of cells like macrophages, dendritic cells (DC) and on other cells. TLR (TLR1-TLR9) enable activation of the innate immunity effectors, as well as signals that activate an adaptive immunity. Actually, there are many other proteins which enable the transfer of the signal from TLR to the nuclear factor kappa B (NF-kB), which is responsible for induction of expression of several genes being involved in inflammatory and immune response.In chicken a lower number of TLR (TLR1, TLR2, TLR3) than mammals has been found. In addition, recent search of chicken EST sequences identified genes for proteins with known involvement in the TLR pathway (IRAK4, MAL, MyD88, TRAF6), but did not find homologues of some TLRs, or IRAK1, IRAK2 and IRAK9 as well as other proteins of TLR signalling pathway. So, those novel data enable more targeted investigations of interactions between chicken cells (or tissues) and the selected pathogen.It seems that, generally, chicken TLR2 can recognize lipoproteins which are major but variably expressed antigens in several Mycoplasma spp. It is known that hemagglutinins of MG and MS are lipoproteins but their interactions with chicken cells e.g. macrophages, DC, lymphocytes (B and T) and other cells are not known. Using modern tools of functional genomics (microarrays, RT-PCR, mAbs) we will investigate host pathogen interactions in the chicken model during the MG and MS infection.
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