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Projects / Programmes source: ARIS

Development of tissue engineered bone for use in periodontology, traumatology and orthopaedic surgery

Research activity

Code Science Field Subfield
4.06.00  Biotechnical sciences  Biotechnology   

Code Science Field
T490  Technological sciences  Biotechnology 
B580  Biomedical sciences  Skeleton, muscle system, rheumatology locomotion 
Keywords
tissue engineering; bone; cell culturing; biomaterials; osteoblasts; mesenchymal stem cells; phenotype analysis; orthopedy; periodontology
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  03937  PhD Miran Čeh  Materials science and technology  Researcher  2004 - 2007  655 
2.  21500  PhD Matej Drobnič  Neurobiology  Researcher  2004 - 2007  255 
3.  05216  Medeja Gec    Technical associate  2004 - 2007  42 
4.  05986  Bogomir Gorenšek  Neurobiology  Researcher  2004 - 2007  91 
5.  23597  PhD Matevž Gorenšek  Neurobiology  Junior researcher  2004 - 2007  76 
6.  01302  PhD Matjaž Jeras  Biotechnology  Researcher  2004 - 2007  365 
7.  10038  PhD Miomir Knežević  Biotechnology  Head  2004 - 2007  298 
8.  14344  Branko Koritnik  Neurobiology  Researcher  2004 - 2007  55 
9.  21227  PhD Metka Krašna  Biotechnology  Researcher  2004 - 2007  49 
10.  16002  PhD Nevenka Kregar Velikonja  Biotechnology  Researcher  2004 - 2007  322 
11.  22646  PhD Darja Marolt Presen  Biochemistry and molecular biology  Junior researcher  2004 - 2006  79 
12.  15475  PhD Vinko Pavlovčič  Neurobiology  Researcher  2004 - 2007  193 
13.  14343  Damjan Radosavljevič  Neurobiology  Researcher  2004 - 2007  86 
14.  07021  PhD Matjaž Rode  Stomatology  Researcher  2004 - 2007  137 
15.  15597  PhD Zoran Samardžija  Materials science and technology  Researcher  2004 - 2007  583 
Organisations (5)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  91,921 
2.  0311  Blood Transfusion Centre of Slovenia  Ljubljana  5053960  1,759 
3.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,929 
4.  1324  Community Health Centre Ljubljana  Ljubljana  5056063  2,980 
5.  7421  EDUCELL cell therapy service Ltd. Ljubljana  Trzin  1198327  391 
Abstract
Bone repair is an attractive and natural target for tissue engineering, as bone regeneration is needed for the therapy of numerous serious clinical indications. For example: in large segmental defects of diaphyseal bone, connected with acute injury as well as in other massive defects, present secondary to congenital malformations, benign and malignant tumors or osseous infections. In addition, there is a substantial need for bone regeneration therapy in spinal arthrodesis, fixation of prosthetic implants and restoration of maxilofacial structures. Currently, autogenous bone is most frequently used by surgeons and is the graft treatment of choice to augment and restore deficient osseous structures. Unfortunately, for many patients, there is insufficient autologous material available. Consequently, allogeneic bank bone is an alternative. However, allogeneic bone has limitations that may include viral contamination and perhaps postoperative complications. Alternatives to autologous and allogeneic preparations are also different biocompatible materials, such as calcium-phosphates, biologically active glass, polymers and several combinations of bone derivatives, usually based on collagen. Sometimes, combinations of biomaterials and growth factors are used. The listed biocomparible materials represent the basis for tissue engineering of bone. Tissue-engineered bone substitute is composed of (a) scaffold (biocompatible and biodegradable material), (b) cells with osteogenic potential and optionally (c) signal molecules that will promote cell recruitment, mitogenesis, differentiation and renewal. The aim of our work is to develop biological substitute for bone that will enable successfull and fast regeneration of vital bone tissue with adequate biomechanic properties. After first successfull experiments of isolation, cultivation and differentiation of bone cells, we plan to test the suitability of different biocompatible and biodegradable materials as scaffolds for cultivation of cells with osteogenic potential. We will focus on biomaterials that are already being used in clinical pactice for the filling of bone defects. We want to develop bone substitute based on patient"s autologous cells for reconstruction of damaged bone in periodontology, orthopedy and traumatology.
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