Projects / Programmes source: ARIS

How cyclic peptides from cyanobacteria influence biodiversity?

Research activity

Code Science Field Subfield
1.03.00  Natural sciences and mathematics  Biology   

Code Science Field
B260  Biomedical sciences  Hydrobiology, marine biology, aquatic ecology, limnology 
Toxic cyanobacteria, biodiversity, cyclic peptides, cyanobacterial blooms, microcystin
Evaluation (rules)
source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  22616  PhD Tina Eleršek  Biology  Researcher  2005 - 2008  260 
2.  12449  PhD Robert Frangež  Veterinarian medicine  Researcher  2005 - 2008  280 
3.  07744  PhD Gorazd Kosi  Biology  Researcher  2005 - 2008  359 
4.  07736  PhD Bojan Sedmak  Biochemistry and molecular biology  Head  2005 - 2008  232 
5.  18348  Karmen Stanič    Technical associate  2006 - 2008  54 
6.  22588  PhD Monika Cecilija Žužek  Veterinarian medicine  Researcher  2005 - 2008  67 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784  13,274 
2.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,798 
The main goal of the proposed project is to investigate how various cyclic peptides that are simultaneously released from cyanobacterial cells, affect different organisms that come in contact with them and how they affect biodiversity. Namely there are several indications that cyclic peptides from cyanobacteria lower the biodiversity. Firstly we will isolate and optimize the isolation of different cyclic peptides from cyanobacterial cells. Isolated and purified cyclic peptides will be tested in vitro on different phytoplankton representatives. We will monitor the effects on the cellular as well as on the subcellular level by HPLC, epifluorescent and confocal laser microscope. In natural environment the organisms are never exposed only to an isolated biologically active substance, therefore we will study the possible co-operative effects of different cyclic peptides that are usually produced in bloom forming cyanobacteria such as microcystins and cyclic depsipeptides. This is our next step in order to determine the ecological role of cyclic peptides in the water environment and in the origin of cyanobacterial blooms. The importance of this work is a contribution to preservation of biodiversity in water environment.
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