Projects / Programmes source: ARIS

Genetic susceptibility to gastrointestinal complex diseases and pharmacogenomics

Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B220  Biomedical sciences  Genetics, cytogenetics 
B007  Biomedical sciences  Medicine (human and vertebrates) 
B500  Biomedical sciences  Immunology, serology, transplantation 
avtoimmune diseases, inflammatory bowel diseases, Chron's disease, molecular genetics, genotypyng, mutational analysis, gene expression analysis,quantitative PCR, functional genomics, farmacogenomics, regulatory SNPs, haplotypes, linkage disequilibrium, allele specific expression
Evaluation (rules)
source: COBISS
Researchers (23)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  05483  PhD Milan Brumen  Physics  Researcher  2005 - 2008  441 
2.  26447  PhD Andrej Dobovišek  Physics  Researcher  2005 - 2008  109 
3.  09275  PhD Damjan Glavač  Chemistry  Researcher  2005 - 2006  558 
4.  10337  PhD Alojz Ihan  Microbiology and immunology  Researcher  2005 - 2008  1,428 
5.  13343  PhD Nadja Kokalj Vokač  Oncology  Researcher  2005 - 2008  442 
6.  03782  PhD Peter Kokol  Computer science and informatics  Researcher  2005 - 2008  1,208 
7.  25991  PhD Andreja Nataša Kopitar  Microbiology and immunology  Technical associate  2005 - 2008  188 
8.  21863  PhD Srečko Kovačič  Human reproduction  Researcher  2005 - 2007  48 
9.  02053  PhD Ivan Krajnc  Microbiology and immunology  Researcher  2005 - 2008  615 
10.  24404  PhD Matej Mertik  Computer science and informatics  Researcher  2005 - 2008  123 
11.  25809  PhD Vid Mlakar  Metabolic and hormonal disorders  Junior researcher  2005 - 2006  96 
12.  23927  Andreja Ocepek  Oncology  Researcher  2005 - 2008  153 
13.  20129  PhD Dušica Pahor  Metabolic and hormonal disorders  Researcher  2005 - 2008  771 
14.  16340  PhD Uroš Potočnik  Microbiology and immunology  Head  2005 - 2008  620 
15.  22439  PhD Petra Povalej Bržan  Systems and cybernetics  Researcher  2005 - 2008  202 
16.  01502  PhD Metka Ravnik-Glavač  Biochemistry and molecular biology  Researcher  2005 - 2006  264 
17.  28417  PhD Katja Repnik  Microbiology and immunology  Junior researcher  2008  132 
18.  18035  PhD Pavel Skok  Metabolic and hormonal disorders  Researcher  2005 - 2008  667 
19.  29750  PhD Janez Šimenc  Microbiology and immunology  Researcher  2008  24 
20.  24411  PhD Gregor Štiglic  Public health (occupational safety)  Junior researcher  2005 - 2008  474 
21.  25425  PhD Mateja Verlič  Computer science and informatics  Junior researcher  2005 - 2008  77 
22.  13152  PhD Damijan Vokač  Cardiovascular system  Researcher  2005 - 2008  163 
23.  17876  PhD Milan Zorman  Computer science and informatics  Researcher  2005 - 2008  352 
Organisations (4)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,031 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  45,364 
3.  0796  University of Maribor, Faculty of Electrical Engineering and Computer Science  Maribor  5089638003  27,322 
4.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,232 
The aim of our study is to provide new molecular diagnostic markers and molecular targets for novel drugs design for better prevention and treatment of complex gastrointestinal diseases. We will study both major forms of inflammatory bowel diseases (IBD), ulcerative colitis and Crohn disease, IBD-associated neoplasia (IBDNs) and colorectal cancer (CRC). We will focus on identification of novel single nucleotide polymorphisms (SNPs) associated with higher risk for complex gastrointestinal diseases and different individual response to treatment. We will describe new genes and molecular pathways involved in pathogenesis and treatment response. We will develop new bioinformatic and statistical genetic tools for best candidate gene selection. We will develop new approach for identification of functional SNPs in regulatory cis-acting regions based on allele specific expression in lymphoblastoid cell lines from CEPH families and segregation analysis. The database with genes showing most significant allele specific expression will be used for our disease association study and will be avaiable on the internet to scientific community for other disease association studies. We will also describe molecular alterations, including somatic mutations, methylation status and global gene expression profile in adenomas from IBDN patients, tumors from CRC patients and biopsies from IBD patients during standard treatment with corticosteroids and immunosuppresives and treatment with monoclonal antibody inhibitor against TNF alfa (Inflaximab). We will provide molecular markers for IBDN patients with increased risk for CRC development. We will correlate genetic data with CRC patients prognosis and survival. We will functionally characterize genes and proteins most significantly associated with disease. We will establish a comprehensive follow-up patients database and bioinformatic tools for finding statistical correlations between molecular genetic and clinicopathological data included in the database. We will conduct case-control study of patients with gastrointestinal complex diseases and matching healthy individuals using candidate gene, genome-wide haplotype and linkage disequilibrium association aproaches. We will use Taqman method for high-throughput genotyping. Candidate genes genotyped will include drug metabolizing enzymes (phase 1 and phase 2), drug transporters and genes potentially involved in pathogenesis selected in our study using bioinformatics and gene expression approaches. We will use oligo-microarrays, quantitative real time PCR (Taqman) and imunohistochemistry for expression profiling.
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