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Projects / Programmes source: ARIS

NERVE-SPARING RADICAL HYSTERECTOMY

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B570  Biomedical sciences  Obstetrics, gynaecology, andrology, reproduction, sexuality 
Keywords
cervical cancer, radical hysterectomy, nerve-sparing, urodynamics, histologic analysis
Evaluation (rules)
source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  13314  PhD Matija Barbič  Human reproduction  Researcher  2005 - 2008  170 
2.  19450  Branko Cvjetićanin  Human reproduction  Researcher  2005 - 2008  178 
3.  18531  Jožica Gruden    Technical associate  2005 - 2008 
4.  17635  Klementa Habjan    Technical associate  2005 - 2008 
5.  06970  PhD Borut Kobal  Human reproduction  Researcher  2005 - 2008  420 
6.  17638  Meta Kovačič Lužnik    Technical associate  2005 - 2008 
7.  06171  PhD Adolf Lukanovič  Human reproduction  Researcher  2005 - 2008  781 
8.  13515  PhD Leon Meglič  Human reproduction  Researcher  2005 - 2008  151 
9.  06173  Andrej Možina  Human reproduction  Researcher  2005 - 2008  172 
10.  24117  Andreja Natlačen    Technical associate  2005 - 2008 
11.  22159  Martina Pečlin    Technical associate  2005 - 2008 
12.  14534  Mojca Pirc  Human reproduction  Researcher  2005 - 2008  23 
13.  02355  PhD Stelio Rakar  Human reproduction  Head  2005 - 2008  272 
14.  21362  PhD Špela Smrkolj  Human reproduction  Researcher  2006 - 2008  304 
15.  07183  Jasna Šinkovec  Human reproduction  Researcher  2005 - 2008  134 
16.  24116  Maruša Zalar    Technical associate  2005 - 2008 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,764 
Abstract
In Slovenia, the women with cervical cancer (FIGO stages IA2, IB, and IIA) are treated surgically. A new aspect of radical hysterectomy, emphasized in the last few years is the so-called »nerve sparing« technique, i.e. preservation of the lower urinary tract innervation, which essentially reduces mutilant consequences of surgery, leaving the function intact. Descriptions of the nerve sparing techniques are based on most recent anatomical findings on lower urinary tract innervation, and the Ljubljana group have gained some experience with it as well. Our aim is to improve the anatomical knowledge of pelvic innervation and further develop the surgical technique. Therefore, the women consenting to participate in the study will before surgery undergo standard urinary measurements, which will give us the insight into the functional features of the lower urinary tract prior to surgery. Should the procedure allow, we will prepare the posterior, lateral and anterior parametrium following the principles of the of nerve sparing technique. The amount of nerve fibers, contained in the resected parametria will be evaluated using special histologic staining (S-100). After surgery, we will follow the women’s recovery: duration of catheterization, possible retention of the urine, and we will repeat urodynamic measurements at 3–6 months, and at 12 months. The women planned for radiotherapy will be excluded. The analysis will involve a thorough comparison of the bladder function between the women in whom the nerve-sparing technique was used and those in whom it was not possible to use it; the bladder function will be compared in terms of the width of the vaginal cuff, and the amount of nerve fibers contained in the resected parametria analyzed. On the basis of obtained results we will be able to confirm or reject the opinions on innervation pathways of the lower urinary tract, improve our skills in using the »nerve sparing« surgical technique, and, possibly, suggest new standards for preparation of the posterior, lateral and anterior parametria at radical hysterectomy.
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