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Projects / Programmes source: ARIS

Biochemical and clinical factors affecting recurrency of meningioma after neurosurgical resection

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B200  Biomedical sciences  Cytology, oncology, cancerology 
B520  Biomedical sciences  General pathology, pathological anatomy 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
brain tumors, meningiomas, recurrency, tumor markers, caspase, survivin, cathepsins
Evaluation (rules)
source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11308  PhD Andrej Cör  Oncology  Researcher  2005 - 2006  405 
2.  15407  Gvido Gumzej  Neurobiology  Researcher  2005 - 2007  11 
3.  20251  PhD Boštjan Matos  Neurobiology  Researcher  2005 - 2008  45 
4.  07090  PhD Mara Popović  Neurobiology  Researcher  2005 - 2006  306 
5.  07031  PhD Borut Prestor  Neurobiology  Head  2005 - 2008  191 
6.  18471  PhD Andrej Vranič  Neurobiology  Researcher  2005 - 2008  59 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,699 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  47,545 
Abstract
The prospective and randomized controlled trial will be used to establish the effect of the individual active ingredients, given through the epidural catheter, on the depth of the anesthesia. For patients, who have undergone a thorax surgery, for some time we have been using a combination of a general and local anesthesia with the help of the thoracic epidural catheter (TEA). Besides providing an effective analgesia TEA has many other useful effects: reducing the stress reaction of the patient’s body to the surgery, a little likelihood of a deep vein thrombosis, protection of the myocardial muscle from the harmful functioning of the sympathetic autonomous nervous system, faster recovery of a patient, facilitating post-operative physiotherapy of a patient, fewer post-operative complications… During these operations the general anesthesia is maintained by a venous or vapor anesthetics. Due to the side effects they have when used in a larger doses, they are used in a combination. The patient can therefore be given smaller doses of the individual anesthetic, which helps us to avoid the harmful side effects. Nevertheless, an appropriate depth of the anesthesia and the patient’s sleep respectively has to be ensured. The best way to monitor the depth of the anesthesia during a surgery is to use the bispectral index (BIS). It is a simple, non-invasive and patient-friendly method. The individual researches have shown that the epidural active ingredients also have a sedative effect. Therefore, for an appropriate depth of the anesthesia, smaller doses of other anesthetics are required. The aim of this study is to establish, which active ingredient has the greatest impact on the depth of the anesthesia and should be taken into account when preparing the standard epidural mixtures. If the results of the study show that the given active ingredient has an important impact on the depth of the anesthesia, we will be able to reduce the doses of the other anesthetics and by this avoid their side effects and last but not least cheapen the thorax surgeries. The already established active ingredients, which are usually used in the epidural anesthesia (bupivacaine, levo-bupivacaine, ropivacaine, clonidine and morphine), will be tested.
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