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Projects / Programmes source: ARIS

STUDY OF EVOKED CEREBRAL BLOOD FLOW UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
Evoked cerebral blood flow, Carotid stenting, Transcranial doppler, Functional magnetic resonance
Evaluation (rules)
source: COBISS
Researchers (12)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15151  PhD Fajko Bajrović  Neurobiology  Researcher  2005 - 2008  337 
2.  18480  Valentin Beznik    Technical associate  2005 - 2008 
3.  21239  PhD Blaž Koritnik  Medical sciences  Junior researcher  2005 - 2008  275 
4.  20712  MSc Zoran Miloševič  Cardiovascular system  Researcher  2005 - 2008  113 
5.  05347  PhD Tomaž Pogačnik  Neurobiology  Researcher  2005 - 2008  165 
6.  16365  PhD Janja Pretnar Oblak  Neurobiology  Researcher  2005 - 2008  370 
7.  05349  PhD Alenka Sever  Public health (occupational safety)  Researcher  2005 - 2008  58 
8.  20836  Andrej Sirnik  Medical sciences  Researcher  2005 - 2008  24 
9.  10592  PhD Viktor Švigelj  Neurobiology  Researcher  2005 - 2008  220 
10.  11647  PhD Marjan Zaletel  Neurobiology  Researcher  2005 - 2008  724 
11.  17693  Anka Žekš    Technical associate  2005 - 2008 
12.  05352  PhD Bojana Žvan  Neurobiology  Head  2005 - 2008  801 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,742 
Abstract
Evoked cerebral blood flow (ECBF) is important for cerebral metabolism and normal brain function. Transcranial Doppler sonography (TCD) enables monitoring of ECBF in the middle and posterior cerebral arteries. Functional magnetic resonance imaging (fMRI) enables approximate measurements of the volume of activated brain tissue. With a combination of TCD and fMRI we could find out what the ECBF per unit of activated brain tissue is and investigate the function of neurovascular units. Hemodynamically important internal carotid artery stenosis can cause impairment of neurovascular unit function. Similar kind of impairment can be seen in migraine patients. So far it is not clear if carotid angioplasty with stenting (CAS) improves the function of the neurovascular unit. Therefore, the aim of our study was to find out if combination of TCD and fMRI enables detection of neurovascular units function in healthy subjects, if patients with hemodynamically important internal carotid artery stenosis have impairment of neurovascular unit function and if this function improves after carotid endarterectomy. The records will be made from 40 patients with hemodynamically important internal carotid artery stenosis before and after CAS and 10 healthy volunteers of similar age, gender and dexterity. During TCD and fMRI the patients will grip their hands with frequency that will be 50 % of the maximal frequency.
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