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Projects / Programmes source: ARIS

Influencing chondrocyte differentiation phenotype 'in vitro' by 3D scaffolds

Research activity

Code Science Field Subfield
7.00.00  Interdisciplinary research     

Code Science Field
T490  Technological sciences  Biotechnology 
Keywords
chondrocytes, hydrogel, cell phenotype, differentiation, autologous chondrocyte implantation
Evaluation (rules)
source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15627  PhD Ariana Barlič  Biochemistry and molecular biology  Head  2005 - 2008  90 
2.  16341  MSc Orjeta Bonaca  Microbiology and immunology  Researcher  2005 - 2006  16 
3.  21500  PhD Matej Drobnič  Neurobiology  Researcher  2005 - 2008  255 
4.  25484  PhD Mirjam Fröhlich  Biotechnology  Junior researcher  2005 - 2008  55 
5.  28888  Danica Gantar  Pharmacy  Technical associate  2007 - 2008 
6.  01302  PhD Matjaž Jeras  Biotechnology  Researcher  2005 - 2008  363 
7.  10038  PhD Miomir Knežević  Biotechnology  Researcher  2005 - 2008  296 
8.  19120  PhD Hana Krečič Stres  Biotechnology  Researcher  2007 - 2008  50 
9.  16002  PhD Nevenka Kregar Velikonja  Biotechnology  Researcher  2005 - 2008  318 
10.  21228  PhD Elvira Maličev  Microbiology and immunology  Researcher  2005 - 2006  147 
11.  28889  Nadja Polanc    Technical associate  2007 - 2008 
12.  26275  Saša Puhar  Biotechnology  Technical associate  2007 - 2008 
13.  14343  Damjan Radosavljevič  Neurobiology  Researcher  2005 - 2008  86 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0311  Blood Transfusion Centre of Slovenia  Ljubljana  5053960  1,736 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,359 
3.  7421  EDUCELL cell therapy service Ltd. Ljubljana  Trzin  1198327  646 
Abstract
We are confronting two problems at autologous chondrocyte implantation: chondrocyte dedifferentiation in monolayer culture and invasiveness of surgical procedure. Our intention is to make a tissue-engineered construct of three-dimensional gel scaffold that promotes chondrocyte cell phenotype and enables less invasive operation procedure. To monitor the differentiation state of chondrocytes a method for quantitative evaluation of gene expression by real-time PCR will be introduced.
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