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Projects / Programmes source: ARIS

The study of new quinolone antibiotic complexes

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Research activity

Code Science Field Subfield
1.04.03  Natural sciences and mathematics  Chemistry  Inorganic chemistry 

Code Science Field
P003  Natural sciences and mathematics  Chemistry 
P360  Natural sciences and mathematics  Inorganic chemistry 
Keywords
quinolones, metal ions, complexes, synthesis, characterization, biological activity, interactions with DNA
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (1)
no. Code Name and surname Research area Role Period No. of publications
1.  11053  PhD Iztok Turel  Chemistry  Head  1998 - 2001  598 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,084 
Abstract
New solid state complexes of quinolone antibacterial agents will be prepared. Quinolones already used in clinical praxis as well as some less known quinolones will be used as starting materials. The reactions with various metal ions will be performed especially those that have not been used in our previous studies. Among these the most interesting ions are vanadium, titanium, magnesium and cobalt. If necessary some other metal ions will also be used. The reactions will be carried out in different solvents. It was namely discovered that some products could not be isolated from aqueous medium. The reactions of different copper salts with quinolones will also be continued and the products will be compared with previously isolated copper-quinolone complexes. All isolated compounds will be characterized by selected physico-chemical methods (elemental analyzes, thermal analysis, spectroscopic methods, X-ray analysis, etc.). The biological tests of the compounds will be performed in the cooperation with appropriate laboratories. We also intend to study the bonding of quinolones and their metal complexes to DNA or smaller parts of this molecule.
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