Filters
cris logo
-
New search Filters
Select from list
Displayed from Show more
You have reached the maximum number of displayed search results.
All results displayed
No results are available for the search performed
Displayed from
You have reached the maximum number of displayed search results.
All results displayed
Loading results
Obtaining statistical data

Projects / Programmes source: ARIS

Cross-talk between cell cycle regulation and cholesterol & drug metabolism in the mammalian liver

Edit
Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
B200  Biomedical sciences  Cytology, oncology, cancerology 
P320  Natural sciences and mathematics  Nucleic acids, protein synthesis 
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
Keywords
cell cycle, apoptosis, liver cancer, cholesterol homeostasis, xenobiotic metabolism
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (2)
no. Code Name and surname Research area Role Period No. of publications
1.  20347  PhD Klementina Fon Tacer  Metabolic and hormonal disorders  Researcher  2005 - 2007  126 
2.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Head  2005 - 2007  1,054 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,255 
Abstract
With the proposed project we endeavor exploit the cross-talk between cell cycle regulation and cholesterol homeostasis and drug metabolism in liver. Humans are exposed to broad spectrum of xenobiotics that activate nuclear receptors. Their chronic activation can lead to liver tumorigenesis. Disrupted cholesterol homeostasis is one of the malignant transformation of cancer cells. We will investigate cholesterol biosynthesis in different stages of cell cycle as well as the impact of nuclear receptor activation on hepatocyte cell cycle and apoptosis regulation.
Confirmation required
Views history
Favourite