Development of Mur Ligase Inhibitors as Novel Antibacterial Agents     

The main purpose of the research project is the development of novel antibacterial agents. In order to challenge the infections caused by resistant bacterial strains novel targets are considered, among which the enzymes of bacterial cell wall synthesis Mur ligases are considered as most promising ones. Already published basic mechanistic features and crystal structures of Mur ligase enzymes as well as few known Mur inhibitors will give the starting point for development of novel potent Mur ligase inhibitors. Various modern techniques of rational drug design and organic synthesis will be applied in order to develop drug-like Mur ligase inhibitor candidate for clinical trials.