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Projects / Programmes source: ARRS

The importance of new methods of advanced heart failure treatment

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Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B530  Biomedical sciences  Cardiovascular system 
Keywords
advanced heart failure, new methods of tretment, levosimendan, stem cells
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publications
1.  24927  PhD Miran Brvar  Medical sciences  Researcher  2007 - 2009  552 
2.  15667  PhD Matjaž Bunc  Medical sciences  Principal Researcher  2007 - 2009  512 
3.  16254  PhD Andreja Černe  Medical sciences  Researcher  2007 - 2009  66 
4.  18259  Irena Orel    Technician  2007 - 2009  0 
5.  02020  PhD Radovan Starc  Medical sciences  Researcher  2007 - 2009  192 
6.  18826  PhD Bojan Vrtovec  Medical sciences  Researcher  2007 - 2009  477 
7.  10726  PhD Igor Zupan  Medical sciences  Researcher  2007 - 2009  284 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  74,065 
Abstract
Chronic heart failure is clinical menifestation of diminished heart pumping function as a result of different diseases. Ischemic heart disease, miocarditis, heart valvular diseases, untreated arterial hypertension, arrhythmias, development anomalies, metabolic disturbances (tyroid dysfunction) are most frequent causes of heart failure. Besides of well established medicamentous treatment of advanced heart failure a novel therapeutic approches emerged. Levosimendan influences cardiac contractility through sensitation of myofibrils for calcium. Stem-cell therapy is another promising method of advanced heart failure tretment. In our research the clinical value of levosimendan and stem cell therapy treatment will be evaluated.
Significance for science
The results of the study were presenten in many abstracts and oral presentatins in the most important international meetings (ACC 2009, AHA 2008, TRANSPL 2007,2008,2009..). The results of treatment of advanced heart failure due to primary dilatative CMP are one of rear in the world. They already have impact on international recommanadtions for the CMP treatment.
Significance for the country
The results of patients treatment both with steam cells and levosimandan have great impact on our clinical practice. The treatment of patients improve, time of in hospital staying is shorted, number of re-hospitalisation decreased, patients quality of life improved.
Most important scientific results Annual report 2008, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2008, final report, complete report on dLib.si
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