Projects / Programmes
In vivo imaging temporal and spatial dynamics of calcium homeostat during systemic inflammatory response to endotoxins
| Code |
Science |
Field |
Subfield |
| 4.06.00 |
Biotechnical sciences |
Biotechnology |
|
| Code |
Science |
Field |
| T490 |
Technological sciences |
Biotechnology |
| B510 |
Biomedical sciences |
Infections |
calcium signalisation; bio-sensor; in vivo imaging; inflammatory response; endotoxins
Researchers (5)
Organisations (1)
| no. |
Code |
Research organisation |
City |
Registration number |
No. of publicationsNo. of publications |
| 1. |
0104 |
National Institute of Chemistry |
Ljubljana |
5051592000 |
21,007 |
Abstract
Particularly in the European environment, information society became a major challenge which instigated a lasting interest in the formulation of principles and methods which tackle the problem of transferring various information related to language. The recognition of the need for free communication which can be realized only within one's own mother tongue lead to the widely accepted principle of assuring creative freedom of each individual in his/her own language, together with the possibility of exchanging information with other languages. This is true for all domains of human activity and creativity, in a knowledge-based society, however, scientific and professional communication – where one is confronted with the so-called specialized knowledge – is particularly emphasized. Terminology management is very important for this type of communication, with a specialized dictionary for each specific professional or scientific field lying at its core.
The goals of the research project are the following: The overview of terminology resources: the research aims at establishing which resources are available for the Slovenian language and to measure the interest for cooperation in different professional fields. As there are various terminology portals available for other languages, our intention is to examine the existing solutions and to evaluate them from the point of view of the specific Slovenian situation. The main objective of the project is to develop the Slovenian terminology portal which would offer basic information on the principles of terminological work and above all make available software tools for presenting terminology in a unified format. It will be designed to enable the compilation of different types of terminological dictionaries to all the interested parties which would be designed and presented in a unified manner. These terminological resources will be publicly available on the web. Simultaneously, the feasibility of linking textual resources with the terminological database will be tested. We wish to examine to what extent terminologically relevant data can be extracted from Slovenian corpora with (semi)automated procedures, which can be later used as the basis.
Significance for science
Our results are important for understanding the mechanism of systemic inflammatory response at virus and bacterial infection. Results represent a link between molecular pattern recognition with Toll like receptors and downstream signaling. We determined the binding of double stranded RNA to TLR3 receptor, which we published in scientifically high ranking magazine. This knowledge is important for understanding the physiological processes in cells and organisms as well as a prerequisite for rational drug design.
Results of the project enabled the development of two genetically encoded biosensors and their usufulness was demonstrated in model organisms. The development of biosensors and their application in the biomedical model is of the utmost importance in today's biology. Application of biosensors in biological systems in combination with other methods of molecular biology (genomics, functional genomics and proteomics) has enabled us to determine the role of calcium in the internalisation mikroveziklov and research applications endosomalne pH in inflammatory signal processing.
Knowledge of the mechanisms of molecular recognition is important for understanding the physiological processes in cells and organisms and is indispensable for the design of active pharmaceutical ingredients.
Significance for the country
Promotion of the state abroad. The project results were published in internationally well established scientific journals, which is important for relevance of the results. The innovative technologies and methodologies were disseminated via presentations at conferences, publications and via student courses.
Promotion of science. We successfully promoted the natural science to the general audience in Slovenia and abroad via excellent success in the competition of research projects among the most eminent academic competitors. The undergraduate students were integrated in the research project.
Mobility in science. We intensifed established international collaborations by promoting short exchange visits of researchers and knowledge transfer that increased the mobility in science. We supported an exchange of postgraduate students.
Education. Young researchers and diploma students were included into the research which increased number of highly educated researchers. The proposed research also centers innovative methods and technology which is available for scientific community and industry. Via lectures, lay and expert publications the knowledge was available to experts as well as wide audience.
Most important scientific results
Annual report
2008,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2008,
final report,
complete report on dLib.si
