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Projects / Programmes source: ARIS

Chronic renal failure - new risk factor for stroke

Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
B560  Biomedical sciences  Urology, nephrology 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
B530  Biomedical sciences  Cardiovascular system 
Keywords
chronic renal failure, stroke, cystatin C, creatinine, risk factors
Evaluation (rules)
source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  23191  PhD Robert Ekart  Cardiovascular system  Researcher  2007 - 2009  637 
2.  07616  MSc Maksimiljan Gorenjak  Human reproduction  Researcher  2007 - 2009  206 
3.  15751  PhD Radovan Hojs  Metabolic and hormonal disorders  Head  2007 - 2009  794 
4.  18036  PhD Tanja Hojs-Fabjan  Neurobiology  Researcher  2007 - 2009  244 
5.  20129  PhD Dušica Pahor  Metabolic and hormonal disorders  Researcher  2007 - 2009  777 
6.  15749  PhD Breda Pečovnik Balon  Metabolic and hormonal disorders  Researcher  2007 - 2009  335 
7.  18987  PhD Andreja Sinkovič  Cardiovascular system  Researcher  2007 - 2009  582 
8.  02062  PhD Erih Tetičkovič  Cardiovascular system  Researcher  2007 - 2009  251 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  22,561 
Abstract
Stroke is the most common acute neurologic disease (in 2001 reported incidence in Slovenia was 232/100000 people/year) and it is the second commonest cause of death in the world and the third commonest cause of death in USA (after heart disease and cancer). Known traditional risk factors for stroke are hypertension, diabetes, dyslipidemia, age, gender, smoking, physical inactivity, obesity and psychosocial stress. The prevalence of chronic renal failure in patients with stroke is not known and it is also not known if chronic renal failure is another risk factor for stroke and if it has impact on the prognosis of stroke. This is very important because patients with chronic renal failure have high prevalence of atherosclerosis and have higher risk for cardiovascular diseases. The prevalence of coronary artery disease in patients with end-stage renal failure is approximately 40 % and cardiovascular mortality is 10 to 20 times higher than in general population. High prevalence of cardiovascular diseases was also reported in patients starting dialysis treatment and last studies showed accelerated atherosclerosis already in patients with mild to moderate renal failure. It is not known if mild or moderate renal failure has impact on evolution of cerebrovascular disease. Serum creatinine is the most commonly used marker to estimate renal function (the glomerular filtration rate), but it is often not enough accurate, especially in patients with incipient renal failure and in elderly. Recently serum cystatin C has been proposed as a new, more sensitive endogenous marker of glomerular filtration rate. The aim of our study is to find out the prevalence of chronic renal failure in patients with stroke treated in Dept. of Neurology at General hospital Maribor. Possible association between chronic renal failure and other risk factors will be assessed. Important question is if in patients with chronic renal failure different risk factors are presented and if they are coexisting and additive. We also want to find out if chronic renal failure has impact on the prognosis of patients with stroke. Another aim of our study is to evaluate if serum cystatin C is more than a marker of renal function (glomerular filtration rate).
Significance for science
The study is important as it undoubtedly confirmed that renal dysfunction is common in patients with cerebrovascular insult. It has also confirmed that patients with present renal dysfunction have worse prognosis than those without it. It has also showed that certain other risk factors between the group of patients with renal dysfunction and those without differ. Renal dysfunction is not only common in patients with cerebrovascular insult, but also an independent predictor of mortality in these patients. It is related to short-term mortality (in-hospital and 30-day) and also 1-year survival of these patients. Serum cystatin is a better predictor of mortality in these patients, therefore it is sensible to analyse it in these patients.
Significance for the country
The study is important from the standpoint that renal dysfunction is common in patients with cerebrovascular insult and related to further mortality of these patients. The worse the renal function, the worse the prognosis of the patient with cerebrovascular insult. Early search for patients with renal dysfunction and their suitable treatment could prevent the incidence of renal dysfunction/failure. If the dysfunction is already present, it could slow down the progress of renal failure. Long-term, this means fewer costs (also hospitalizations) for these patients, especially since cerebrovascular insult often causes permanent disability and poorer quality of life.
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