Projects / Programmes
Reactive intermediates in the transformation of organic compounds
| Code |
Science |
Field |
Subfield |
| 1.04.04 |
Natural sciences and mathematics |
Chemistry |
Organic chemistry |
| Code |
Science |
Field |
| P390 |
Natural sciences and mathematics |
Organic chemistry |
oxidation, mechanisms of organic reactions, reactive intermediates, ozone, peroxides, polyoxides, photochemistry, polyvalent iodine compounds
Researchers (8)
Organisations (1)
Abstract
(A) (a) Dihydrogen trioxide (HOOOH) and alkyl hydrotrioxides (ROOOH) are key intermediates in the low-temperature ozonization of saturated organic substrates and organometallic hydrides, in atmospheric and environmental chemistry, as well as in normal and pathological processes in the living organisms. The proposed project involves studies of the ozonization of various saturated compounds, i.e., hydrocarbons, aldehydes, thiols, and amino acids, in order to prepare, characterize, and determine the structure and reactivity of these interesting polyoxide intermediates presumably formed in these reactions. (b) The oxidation of substituted N-(methyl-benzylidene)anilines and 4-methylcoumarines with dimethyldioxirane will be studied.
(B) (a) The influence of larger chromophore groups on the nature of the C–X bond scission under selected photochemical conditions will be studied. We will synthesize 4-halosubstituted derivatives of curcumin and study their photolysis, especially from the viewpoint of generating the radical on the methylene group of these compounds. We will also investigate the properties of the C–X bond in the following substrates: 1-halo-1,4-diphenylbut-3-en-2-ones and 4-halo-1,7-diphenylhepta-1,6-dien-3,5-diones. (b) 9-I-2 Iodanyl radicals are possible reaction intermediates in several radical reactions involving organic iodine compounds. We will try to prepare and characterize these unstable intermediates from several suitable precursors; attempts will be made to determine some of the properties of these elusive entities (structure, stability).
Significance for science
Results present original and new cognition from the field of our research. We hope that it will find the interest and will be well cited.
Significance for the country
Our research is connected with undergraduate and postdoctoral studies of chemistry. Good education of students is directly connected with Slovenian development.
Most important scientific results
Annual report
2008,
2009,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2008,
2009,
final report,
complete report on dLib.si
