Projects / Programmes
Estimation of the glomerular filtration rate - comparation and role of different markers
| Code |
Science |
Field |
Subfield |
| 3.07.00 |
Medical sciences |
Metabolic and hormonal disorders |
|
| Code |
Science |
Field |
| B560 |
Biomedical sciences |
Urology, nephrology |
kronična ledvična bolezen, cistatin C, cistatinske formule, kreatinin, kreatininske formula/chronic kidney disease, cystatin C, cystatin C formulas, creatinine, creatinine formulas
Researchers (7)
| no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
| 1. |
27593 |
PhD Sebastjan Bevc |
Cardiovascular system |
Researcher |
2008 - 2011 |
776 |
| 2. |
23190 |
Benjamin Dvoršak |
Cardiovascular system |
Researcher |
2008 - 2011 |
111 |
| 3. |
23191 |
PhD Robert Ekart |
Cardiovascular system |
Researcher |
2008 - 2011 |
664 |
| 4. |
07616 |
MSc Maksimiljan Gorenjak |
Human reproduction |
Researcher |
2008 - 2011 |
207 |
| 5. |
15751 |
PhD Radovan Hojs |
Metabolic and hormonal disorders |
Head |
2008 - 2011 |
805 |
| 6. |
02053 |
PhD Ivan Krajnc |
Microbiology and immunology |
Researcher |
2008 - 2011 |
615 |
| 7. |
15749 |
PhD Breda Pečovnik Balon |
Metabolic and hormonal disorders |
Researcher |
2008 - 2011 |
335 |
Organisations (2)
Abstract
Chronic kidney disease (CKD) is an important public health problem. The estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with CKD. Estimation of GFR is known as the most accurate measurement of filtration ability across all nephrons in healthy persons and in patients. The ideal marker of GFR should be an endogenous molecule which, being produced at a constant rate, is cleared solely by the kidneys via free glomerular filtration, without being neither secreted by tubular cells, nor reabsorbed into peritubular circulation. Until now no such a marker is known. In clinical practice serum creatinine concentration and creatinine clearance are the most commonly used markers to estimate GFR, but often not accurate enough. The standard method for the estimation of GFR is clearance of radionuclide-labeled marker. Recently, serum cystatin C was proposed as a new endogenous marker of GFR. Knowing GFR allow us to detect early impairment of renal function, prevent further deterioration and complications, allow correct dosage of drugs cleared by the kidneys, to monitor renal transplants and to evaluate patients before use of potential nephrotoxic radiographic contrast media. The current studies emphasize the need to assess kidney function using predictive equations or other markers of GFR rather than just serum creatinine, especially for populations like elderly, children and patients with diabetes. One of the most important markers of GFR is serum cystatin C. Compare to serum creatinine concentration serum cystatin C concentration does not depend on muscle mass, sex, age or diet. Serum cystatin C concentration is not affected by inflammation, fever and/or outside agents and malignant diseases. Estimation of GFR using serum cystatin C-based formulas presents additional research field.
The objective of our research project will be evaluation of serum cystatin C and serum cystatin C-based formulas compare to serum creatinine-based formulas and clearance of radionuclide-labeled marker for estimation of GFR in population of patients with CKD, elderly and especially in population of patients with diabetes.
Significance for science
Results of our study asses the role of cystatin C formulas for estimation of renal function. It explane the role of defining of cystatin C and cystatin C-based equation (simple or complex equations) for estimation of glomerular filtration in elderly population and patients with diabetes mellitus and chronic kidney disease. According to our results, in our research project we confirm the superiority of serum cystatin C and cystatin C formulas, compared to serum creatinine, serum creatinine formulas and clearance of radiopharmac marker for estimation of glomerular filtration in patient with chronic kidney disease. The definition of role and meaning of serum cystatin C and cystatin C formulas help us to reach to the exact estimation of renal function, which is especially important by detecting early impairment of renal function, allowing us to dosage correctly drugs cleared by the kidney to avoid potential drug toxicity and helping us to manage chronic kidney disease and transplant patients. Exact definition of renal function allow us to act early and prevent further complication of renal or cardiovascular diseases.
Significance for the country
The prevalence of chronic kidney disease in developing countries is more than 10%. With increasing emphasis on the earlier detection and management of chronic kidney disease, estimation of the glomerular filtration rate has assumed greater importance. According to known disadvantages of estimation of glomerular filtration rate with serum creatinine need for new markers of glomerular filtration rate has accoured. Our results could hepl us to bether detect early renal impairment, to bether monitoring of chronic kidney disease and allow us to manage bether treatement. Precise evaluation of renal function with estimation of glomerular filtration rate will help to find patients with chronic kidney disease and contribute to take measures of prevention, diagnostic and specific therapy. All this will decrease the number of hospitalisation, invalidism, cardiovascular events and deaths caused by renal or cardiovascular disease. The need for expensive diagnostic methods (radiopharmacs) for estimation of glomerular filtration rate will be diminished. Our results will have strong influence on early detection of patients with chronic kidney disease, prevention and diagnostic of cardiovascular diseases in this population.
Most important scientific results
Annual report
2008,
2009,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2008,
2009,
final report,
complete report on dLib.si
