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Projects / Programmes source: ARIS

Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci (Slovene)

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B510  Biomedical sciences  Infections 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Researchers (32)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16235  PhD Maja Arnež  Microbiology and immunology  Researcher  2009 - 2014  184 
2.  08312  PhD Bojana Beovič  Microbiology and immunology  Researcher  2009 - 2014  467 
3.  27886  PhD Petra Bogovič  Microbiology and immunology  Technical associate  2009 - 2014  149 
4.  13302  PhD Jože Cimperman  Microbiology and immunology  Researcher  2009 - 2014  180 
5.  10981  PhD Milan Čižman  Microbiology and immunology  Researcher  2009 - 2012  452 
6.  24040  PhD Milan Črv  Microbiology and immunology  Researcher  2009 - 2014  17 
7.  13300  PhD Matjaž Jereb  Microbiology and immunology  Researcher  2009 - 2014  251 
8.  34820  Lidija Lepen  Medical sciences  Technical associate  2013 - 2014 
9.  16183  PhD Mateja Logar  Microbiology and immunology  Researcher  2009 - 2014  250 
10.  13299  PhD Stanka Lotrič Furlan  Microbiology and immunology  Researcher  2009 - 2014  335 
11.  13298  PhD Vera Maraspin-Čarman  Microbiology and immunology  Researcher  2009 - 2014  255 
12.  11348  PhD Mojca Matičič  Microbiology and immunology  Researcher  2009 - 2014  367 
13.  19481  Jolanda Munih  Microbiology and immunology  Technical associate  2013 - 2014  58 
14.  20254  PhD Katarina Ogrinc  Microbiology and immunology  Researcher  2009 - 2014  89 
15.  30146  Andreja Oven    Technical associate  2009 - 2014 
16.  32184  PhD Lea Papst  Microbiology and immunology  Junior researcher  2009 - 2014  50 
17.  18371  PhD Andreja Pikelj Pečnik  Microbiology and immunology  Researcher  2009 - 2014  61 
18.  33996  Petra Podkrajšek    Technical associate  2012 - 2014 
19.  20473  Mateja Poljanšek    Technical associate  2009 - 2014 
20.  27603  PhD Anja Radšel  Microbiology and immunology  Junior researcher  2009 - 2012  43 
21.  22350  PhD Tereza Rojko  Microbiology and immunology  Researcher  2009 - 2014  110 
22.  20474  Simona Rojs    Technical associate  2009 - 2014 
23.  20475  Andreja Sorman    Technical associate  2009 - 2014 
24.  33995  Jadranka Stojnič    Technical associate  2012 - 2014 
25.  13301  PhD Franc Strle  Microbiology and immunology  Head  2009 - 2014  846 
26.  30270  PhD Klemen Strle  Medical sciences  Researcher  2009 - 2014  77 
27.  24091  PhD Daša Stupica  Microbiology and immunology  Researcher  2009 - 2014  183 
28.  20477  Dragica Štucin    Technical associate  2009 - 2012 
29.  11347  PhD Janez Tomažič  Microbiology and immunology  Researcher  2009 - 2014  414 
30.  24469  PhD Jerneja Videčnik Zorman  Microbiology and immunology  Researcher  2013 - 2014  59 
31.  34858  Darja Vidmar  Microbiology and immunology  Technical associate  2013 - 2014  19 
32.  20472  Marija Žitko    Technical associate  2009 - 2014 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,925 
Significance for science
The aims in this programme were set to fill the void in knowledge on the etiology, course of disease, pathogenic mechanisms, and treatment efficacy for Lyme borreliosis. Since this programme was based in a human system, the knowledge gained might and did influence clinical practice. Moreover, we anticipate that the generated data will foster new areas of investigation to potentially include studies of new spirochetal genotypes, etiology of new tick-borne diseases, factors in acute versus chronic Borrelia infection, and immune mechanisms of post-treatment symptoms. Ad 1. and 2. The obtained data enabled a rational choice of antibiotics for treatment of erythema migrans and rational decisions on duration of the treatment. Ad 3. Acquisition of data not published previously. Since our findings indicate that persistence of borreliae in skin after treatment with antibiotics for 14 days is an extremely rare event, there is no need for prolonged treatment that was used by some clinicians due to the fear of persistance. Ad 4. Completition of very limited data. Our findings indicate that in comparison to immunocompetent patients those with an underlying immunocompromised condition more often have complicated course of early Lyme borreliosis and more frequently need additional antibiotic treatment but as a rule have favourable final outcome. Ad 5. Completition of very limited data. Differences found by comparison of patients with early Lyme borreliosis according to age suggest the role of immune mechanisms in the pathogenesis of the disease and are a stimulus for further studies. Ad 6 and 7. Acquisition of data not published previously. Ad 8 in 9. Comparison of demonstration of intrathecal production of Borrelia antibodies and isolation of Borreliae from cerebrospinal fluid enabled the assessment of sensitivity of intrathecal production of Borrelia antibodies for the diagnosis of Lyme nuroborreliosis. The findings are of substantial parctical value. Additional evaluation of diagnostic value of serological testing of central nervous system infections with different Borrelia species would be needed. Ad 10 and 11. The assessment of the efficacy of the two treatment approaches enables rational antibiotic choice. Because no differences were found, future treatment of patients with suspected chronic Lyme borreliosis will consist of doxycycline, which is a much less expensive drug in comparison to ceftriaxone. Similar approach will be used also for patients with acrodermatitis chronica atrophicans. Ad 12. Acquisition of data not published previously. The obtained data will be of importance for the development of vaccine against Lyme borreliosis. Ad 13. Completition of data that are very limited in European literature. Ad 14. In patients with Borrelia skin culture proven erythema migrans, who had leukopenia and/or thrombocytopenia, concomittant infections with Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum and/or tick-borne encephalitis virus were not found. The findings have influece on the management of patients in everyday clinical practice. Ad 15 in 16. The causes of post-Lyme disease symptoms are unclear. We evaluated the frequency of new or increased symptoms after treatment of erythema migrans with antibiotics and assessed immune characteristics of patients with sustained symptoms. Our results indicate that incomplete improvement is at least partly associated with distinct immune reactivity. These findings provide a new paradigm for the study of postinfectious symptoms in patients with Lyme borreliosis. We have been using similar approaches also for patients with Lyme neuroborreliosis.
Significance for the country
All studies of the research programme (1.-16.) are of indirect importance for the society due to the promotion of the country through new knowledge. Studies with a potential of pronounced direct influence on health care and/or management of patients are listed herein: Ad 1 and 2. The obtained data will enable rational choice of antibiotics for treatment of erythema migrans and rational decisions on duration of the treatment. Ad 4. Our findings indicate that in comparison to immunocompetent patients those with an underlying immunocompromised condition more often have complicated course of early Lyme borreliosis and more frequently need additional antibiotic treatment but as a rule have favourable final outcome. The findings enable a rational treatment approach in immunocompromised patients who develop Lyme borreliosis. Ad 8 in 9. Comparison of demonstration of intrathecal production of Borrelia antibodies and isolation of Borreliae from cerebrospinal fluid enabled the assessment of sensitivity of intrathecal production of Borrelia antibodies for the diagnosis of Lyme nuroborreliosis. The findings are of substantial value for clinical practice. Ad 10. and 11. The assessment of the efficacy of the two treatment approaches will enable rational antibiotic choice. Because no differences were found, future treatment of patients with suspected chronic Lyme borreliosis will consist of doxycycline, which is much less expensive drug in comparison to ceftriaxone. Similar approach will be used also for patients with acrodermatitis chronica atrophicans.
Most important scientific results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
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