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Projects / Programmes source: ARIS

Dinamika prenosa protona v bioloških sistemih (Slovene)

Research activity

Code Science Field Subfield
1.04.01  Natural sciences and mathematics  Chemistry  Phyisical chemistry 

Code Science Field
1.04  Natural Sciences  Chemical sciences 
Evaluation (rules)
source: COBISS
Researchers (4)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  08095  PhD Mojca Kržan  Neurobiology  Researcher  2009 - 2012  272 
2.  15536  PhD Metoda Lipnik Štangelj  Neurobiology  Researcher  2009 - 2011  208 
3.  08611  PhD Janez Mavri  Chemistry  Head  2009 - 2012  368 
4.  20393  PhD Jernej Stare  Chemistry  Researcher  2009 - 2012  158 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,271 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,743 
Significance for science
Hydrogen bond is one of the most important interactions that governs the structure and function of many biological systems. This project resulted in the improved understanding of hydrogen bonding and its role in enzyme active sites, receptors, and hydration of biomolecules. Studies of factors that influence the catalytic step of MAO B is important in the context of the design of novel and improved inhibitors. Our expertize on flavoenzymes is important for the understanding, prevention and treatment of neurodegenerative deseases.
Significance for the country
The project belongs to the filed of health and biomedicine, which is one of the five high-priority fields of science in the Republic of Slovenia. With its long-lasting important role in Slovenian economy, pharmaceutical industry is among the leading disciplines in technological innovation supported by state-of-the-art research. Motivated by substantial added value of novel drugs, particularly as compared with the manufacture of generics, Slovenian pharmaceutical industry is interested in drug design and supporrts research that can potentially lead to the development of new drugs. Previous experience of our research group includes the design of novel drugs up to the pre-clinical level, based on the research of various protein targets and various classes of potential inhibitors. The project group members are also engaged in teaching (Faculty of Pharmacy and Faculty of Medicine at the University of Ljubljana) and their research experience represents important part of the curriculum. Most of our PhD students find employment in the cooresponding fields of industry after graduating, thus pasing the knowledge and experience acquired during their research into the real sector and contributing to the development of economy. The knowledge acquired in the framework of the project will importantly contribute to the development of pharmacy, biomedicine and biotechnology in Slovenia. Additionally, publication of our research in the highly ranked international journals will enhance the role of Slovenian science and contribute to our national identity. Finally, the efforts in the development of novel drugs will contribute to the reputation of Slovenian researchers in the interantaional community.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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