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Projects / Programmes source: ARIS

Znotrajcelični Tollu podobni receptorji in vpliv inhibicije receptorjev TLR pri avtoimunih boleznih (Slovene)

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Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
3.05  Medical and Health Sciences  Other medical sciences 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publications
1.  14360  PhD Mojca Benčina  Biotechnology  Head  2009 - 2012  392 
2.  17915  PhD Helena Gradišar  Biotechnology  Researcher  2009 - 2012  130 
3.  06628  PhD Roman Jerala  Biochemistry and molecular biology  Researcher  2009 - 2012  1,190 
4.  29494  PhD Alenka Kužnik Krajnik  Pharmacy  Researcher  2009 - 2012  19 
5.  34069  PhD Duško Lainšček  Biotechnology  Technical associate  2011 - 2012  148 
6.  34252  Tina Lebar  Biochemistry and molecular biology  Technical associate  2011 - 2012  67 
7.  21426  PhD Mateja Manček Keber  Pharmacy  Researcher  2009  159 
8.  29496  Blaž Nemec  Chemistry  Junior researcher  2009 - 2012  23 
9.  29991  Alja Oblak  Biochemistry and molecular biology  Technical associate  2009 - 2012  60 
10.  17281  Irena Škraba    Technical associate  2009  0 
11.  34253  Jernej Turnšek    Technical associate  2011 - 2012  22 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,007 
Significance for science
Activation of innate immunity response via Toll-like receptors is required for the defence against pathogens; in contrast excessive immune response could initiate the autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis. A treatment of one problem could set in motion another. Understanding the TLR activation as well as the mechanism of intracellular signal transduction is one of the basic problems of immunology. Objectives of proposed research are the possibility to engineer better agonists and antagonists of TLRs, which can be used as anti-inflammatory agents for treatment of diseases such as arthritis, systemic lupus erythematosus, atherosclerosis, autoimmune encephalitis etc. Education. The project has direct importance for society by achieving a high international level of science and education of highly qualified researchers that are important investment for development of economy.
Significance for the country
Promotion of the state abroad. Results were disclosed on conference in Slovenia and abroad and published in international journals. Mobility in science. We collaborate with international collaborations by promoting short exchange visits of researchers and a knowledge transfer that increase the mobility in science. Education. Young researchers and diploma students are included into the research which increased number of highly educated researchers. The proposed research also centers innovative methods and technology which will be available for scientific community and industry. Transfer of knowledge into industry. The development of inventive methods presents an excellent starting point for a business initiative. This year we have filed a patent application based on preliminary results of proposed project.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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