Znotrajcelični Tollu podobni receptorji in vpliv inhibicije receptorjev TLR pri avtoimunih boleznih (Slovene)

Activation of innate immunity response via Toll-like receptors is required for the defence against pathogens; in contrast excessive immune response could initiate the autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis. A treatment of one problem could set in motion another. Understanding the TLR activation as well as the mechanism of intracellular signal transduction is one of the basic problems of immunology. Objectives of proposed research are the possibility to engineer better agonists and antagonists of TLRs, which can be used as anti-inflammatory agents for treatment of diseases such as arthritis, systemic lupus erythematosus, atherosclerosis, autoimmune encephalitis etc. Education. The project has direct importance for society by achieving a high international level of science and education of highly qualified researchers that are important investment for development of economy.

Promotion of the state abroad. Results were disclosed on conference in Slovenia and abroad and published in international journals. Mobility in science. We collaborate with international collaborations by promoting short exchange visits of researchers and a knowledge transfer that increase the mobility in science. Education. Young researchers and diploma students are included into the research which increased number of highly educated researchers. The proposed research also centers innovative methods and technology which will be available for scientific community and industry. Transfer of knowledge into industry. The development of inventive methods presents an excellent starting point for a business initiative. This year we have filed a patent application based on preliminary results of proposed project.