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Projects / Programmes source: ARIS

Metode za povezovanje podatkov in znanja v sistemski biologiji mrež (Slovene)

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Research activity

Code Science Field Subfield
2.07.07  Engineering sciences and technologies  Computer science and informatics  Intelligent systems - software 

Code Science Field
1.02  Natural Sciences  Computer and information sciences 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publications
1.  23399  PhD Tomaž Curk  Computer science and informatics  Researcher  2009  253 
2.  16324  PhD Janez Demšar  Computer science and informatics  Researcher  2009 - 2012  340 
3.  30692  PhD Mateja Hafner  Biochemistry and molecular biology  Junior researcher  2009  25 
4.  21352  PhD Peter Juvan  Human reproduction  Researcher  2009 - 2012  163 
5.  29992  Petra Kaferle  Biochemistry and molecular biology  Researcher  2009 - 2012  21 
6.  29321  PhD Rok Košir  Cardiovascular system  Junior researcher  2009  90 
7.  26460  PhD Mojca Mattiazzi Ušaj  Biochemistry and molecular biology  Junior researcher  2009 - 2010  62 
8.  25792  PhD Minca Mramor  Human reproduction  Researcher  2009 - 2010  61 
9.  20653  PhD Uroš Petrovič  Biochemistry and molecular biology  Researcher  2009 - 2012  292 
10.  28382  PhD Uršula Prosenc Zmrzljak  Public health (occupational safety)  Junior researcher  2009  89 
11.  06013  PhD Damjana Rozman  Biochemistry and molecular biology  Researcher  2010 - 2012  887 
12.  29630  PhD Miha Štajdohar  Computer science and informatics  Junior researcher  2009 - 2012  21 
13.  30142  PhD Marko Toplak  Computer science and informatics  Researcher  2009 - 2012  27 
14.  28519  PhD Lan Umek  Administrative and organisational sciences  Researcher  2009 - 2012  206 
15.  12536  PhD Blaž Zupan  Computer science and informatics  Head  2009 - 2012  531 
16.  30921  PhD Lan Žagar  Computer science and informatics  Junior researcher  2009 - 2012  17 
Organisations (3)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,682 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,215 
3.  1539  University of Ljubljana, Faculty of Computer and Information Science  Ljubljana  1627023  16,239 
Significance for science
The project is developing a computational framework for knowledge discovery from heterogeneous data and knowledge sources in biomedicine and bioinformatics. Data mining in bioinformatics has so far been concentrated on dealing with data coming from a single source. Due to wide availability of various types of biomedical data and information, the integration approaches are urgently required for further advancement of biomedicine and science in general. The proposed project aims to answer this need, and provides and will provides solutions in the form of new methods and their practical and openly available software implementations. Within the project we are demonstrating the utility of the proposed approaches in two important biomedical applications. The reconstitution of the adiponectin homologous pathway in yeast will enable the reconstruction of the human pathway, which will open the possibilities for discovery and development of new drugs for type 2 diabetes and metabolic syndrome. Developed computational methods will help us to experimentally determine the cross-talk between cholesterol homeostasis and drug metabolism in human primary hepatocytes treated by statins. This will contribute to the detection of side effects of statins.
Significance for the country
The developed procedures within the project can significantly contribute to discovery in molecular biology and, by integrating publicly available data/knowledge sources, reduce costs of the genomic research. Slovenia is lacking applied projects in bioinformatics that bring together computational scientists and experimentalist, and we believe that this project is an example of a successful interdisciplinary development of this type in the area.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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