Projects / Programmes
Ugotavljanje infekcije protez pri zamenjavi umetnih sklepov (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.03.00 |
Medical sciences |
Neurobiology |
|
| Code |
Science |
Field |
| 3.02 |
Medical and Health Sciences |
Clinical medicine |
Researchers (10)
Organisations (2)
Significance for science
Aging of the population means that the number of prosthetic joint implantation will dramatically increase. Prosthetic hip implants have been and will be increasing from 1.66 million in 1990 to an estimated 6.26 million in 2050. Helathcare systems are expecting a 137 % increase in costs due to additional surgeries following prosthetic joint implants in the next 25 years. Infection of the prosthetic joint is the most severe complication and it necessitates a second operation. Thorough understanding of the ethiology and progression of the infection is crucial, since no uniform diagnostic criteria or treatment protocols for prosthetic joint infection currently exist. Differentiating infection from other causes for prosthesis loosening is important, since it allows appropriate treatment and optimal use of antibiotics.
Research performed within the presen project has helped in acquiring thorough new knowledge about the mechanisms of prosthetic joint infection, especially in terms of implementing novel methods for such research. The multidisciplinary approach used by the project team enabled tight collaborations between clinicians, basic medical scientists and microbiologists. Such collaboration is crucial for successfully dealing with prosthetic joint infections.
Moreover, results from the present project were relevant enough to be published in excellent journals (J Orthop Res; JBJS, FEMS Microbiol Lett) and monographic publications from outstanding publisher, such as Science Publisher and Springer.
Significance for the country
The present project held a crucial role in transfering preclinical knowledge into clinical practices of Slovenian orthopaedic hospitals, making the scientifi achievements of the project especially relevant to orthopaedics. Moreover, the same results are very relevant for public health and especially present and future patients with prosthetic joints. Improved understanding of prosthetic joint infections, faster diagnosis and improved targeted treatment have all benefited from the results obtained within the project. Prosthetic joint ifections do not affect just the implanted patient by causing pain, impaired motility and lenghty recovery, but they also represent a sizeable financial burden for the healthcare system and society as a whole.
A model for prosthetic joint infection scientific research was established thanks to the specific scientific approach and overall organization of both the project itself and the multidisciplinary project team. This model places the project team as one of the leaders in orthopaedic research, as demonstrated by publications in excellent scientific journals and lectures at world-class conferences. These achievements are consolidating the distinguished place our country holds in the sientific world. The project was interdisciplinary, meaning that it allowed collaborations between different scientific institutions in Slovenia, Europe and beyond.
Most important scientific results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
