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Projects / Programmes source: ARIS

PREOBLIKOVANJE DIHALNIH POTI - ANGIOGENEZA PRI RINITISU IN ASTMI IN VPLIV VEGF POLIMORFIZMOV (Slovene)

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Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publications
1.  25336  Nissera Bajrović  Microbiology and immunology  Researcher  2009 - 2012  195 
2.  25171  PhD Renato Eržen  Microbiology and immunology  Researcher  2009 - 2012  261 
3.  15710  PhD Matjaž Fležar  Cardiovascular system  Researcher  2009 - 2012  553 
4.  22807  PhD Peter Korošec  Microbiology and immunology  Head  2009 - 2012  712 
5.  10921  PhD Mitja Košnik  Microbiology and immunology  Researcher  2009 - 2012  1,562 
6.  23464  PhD Mateja Marc Malovrh  Microbiology and immunology  Researcher  2009  186 
7.  00288  PhD Ema Mušič  Microbiology and immunology  Researcher  2009 - 2012  490 
8.  29300  PhD Matija Rijavec  Microbiology and immunology  Researcher  2009 - 2012  281 
9.  25331  Mira Šilar    Technical associate  2009 - 2012  362 
10.  25178  PhD Sabina Škrgat  Microbiology and immunology  Researcher  2009 - 2012  327 
11.  25317  PhD Mihaela Zidarn  Public health (occupational safety)  Researcher  2009 - 2012  443 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  1613  University Clinic of Respiratory and Allergic Diseases  Golnik  1190997  7,125 
Significance for science
The presence of an inflammatory response and airway remodeling are cornerstones in the pathogenesis of asthma. Airway wall remodeling in asthma involves a number of changes, including important changes at the level of angiogenesis. Angiogenesis is a complex process, and vascular endothelial growth factor (VEGF) is one of the most potent proangiogenic factors and one of the main targets of our research. Such molecules might be feasible targets for next generation of treatment, which should affect airway remodeling. Functional polymorphisms of different genes are probably the main determine of susceptibility for developing airway remodeling. Therefore better understanding of such genetic background should be helpful in evaluating of different asthma phenotypes and in selecting a more appropriate type of therapy. In summary, this project significantly improve the understanding of airway remodeling in asthma, rhinitis and COPD, especially concerning the role of VEGF. With additional clinically validated replication, our findings could significantly contribute to the development of individualized asthma therapy.
Significance for the country
Asthma and allergy are Europe’s most common chronic diseases and their prevalence is increasing. Moreover, we recently showed high asthma prevalence of 16.3% in Slovenian adult population. Even higher numbers were found in pediatric population, as some studies showed that up to one child in three is affected, and trends indicate that in next decade, half of all Europeans may be suffering from an allergy. The addressing of a very important part of asthma developing and progress might be a highly beneficial for quality of life in Slovenia and Europe.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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