Projects / Programmes
Genetska in terapevtska raznolikost bolnikov pri načrtovanju individualizirane terapije pljučnega raka (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.04.00 |
Medical sciences |
Oncology |
|
| Code |
Science |
Field |
| 3.02 |
Medical and Health Sciences |
Clinical medicine |
Researchers (14)
Organisations (2)
Significance for science
Cancer is the major public health issue in whole developed world. With the ageing of the population, a sustained increase in cancer incidence can also be foreseen. Research and new findings in the field of molecular oncology as well as transfer of this knowledge into individualized cancer therapies has already improved efficiency of treatments and prolonged survival of patients with certain forms of cancer, per example breast cancer. Lung cancer still remains one of the most frequent types of cancer and is most common reason for cancer-related death worldwide as well in Slovenia. Therefore , additional research on molecular markers, which will individualize lung cancer treatment and improve survival probabilities is urgently needed.
What gives our project special value, is that we successfullx determined prognostic value of molecular markers for treatment response, like is EGFR, which has until now already been confirmed for use in clinical practice on a large number of unselected patients who were diagnosed, treated and followed at the same medical institution in a routine clinical prectice. Importantly, more methods for specific molecular marker determination were tested and sensibility and reliability of each used method was evaluated. In addition, molecular markers and their prognostic value were assessed in different biological tissues (tumor, metastases, blood). According to the literature, we were one of the first groups who studied and published prognostic value of ERCC1 in SCLC. Also, influence of ABCB1 polymorphisms on response rate to chemotherapy on caucasian population has not been investigated before our study.
Special importance is also in established collaboration with european partners, like is EORTC. Because of the diversity of molecular biomarkers, also so called frequent cancers are becoming rare cancer.s Therefore for new discoveries in these types of cancer and moreover, efficient transfer of new knowledge into individualized treatments of patients such integration and collaboration of research groups across the world is of upmost importance.
Significance for the country
Cancer is the major public health issue in whole developed world. With the ageing of the population, a sustained increase in cancer incidence can also be foreseen. Research and new findings in the field of molecular oncology as well as transfer of this knowledge into routine clinical practice are of utmost importance for good cancer control worldwide. Our research programme was structured to allow for research of new prognostic and predictive molecular tumor markers in lung cancer and allows for a rapid transfer of knowledge into routine clinical practice in Slovenia. The importance of our research is based on the fact that more than 1000 new lung cancer patients are diagnosed in Slovenia each year and that the mortality due to this cancer is still much too high. Better control of lung cancer with improved survival rates and better quality of life of patients’ means saving of costs for the whole society.
Most important scientific results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
