Projects / Programmes
Molekularna nevrobiologija kronične trigeminalne bolečine - študija celičnih in signalnih mehanizmov, ki so vključeni v prevajanje bolečinskih signalov (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.03.00 |
Medical sciences |
Neurobiology |
|
| Code |
Science |
Field |
| 3.04 |
Medical and Health Sciences |
Medical biotechnology |
Researchers (5)
| no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
| 1. |
34542 |
PhD Tanja Bele |
Biochemistry and molecular biology |
Junior researcher |
2011 - 2012 |
14 |
| 2. |
22361 |
PhD Martina Bergant Marušič |
Biochemistry and molecular biology |
Researcher |
2009 - 2010 |
107 |
| 3. |
30917 |
PhD Elsa Fabbretti |
Biochemistry and molecular biology |
Head |
2009 - 2012 |
143 |
| 4. |
04537 |
PhD Mladen Franko |
Control and care of the environment |
Researcher |
2009 |
608 |
| 5. |
29340 |
Katjuša Reja Mozetič |
Control and care of the environment |
Researcher |
2009 |
4 |
Organisations (1)
| no. |
Code |
Research organisation |
City |
Registration number |
No. of publicationsNo. of publications |
| 1. |
1540 |
University of Nova Gorica |
Nova Gorica |
5920884000 |
14,059 |
Significance for science
Chronic pain is a condition that affects significantly the quality of life of many patients. Our project focused mainly on the study of migraine pain, and supports the hypothesis of the existence of an unique physiology of the trigeminal ganglion. These finding suggest that strong sensitization of trigeminal sensory neurons, is an important element responsible for strong headache. One important component in neuronal sensitization is the contribution of extracellular soluble substances that mediate the crosstalk of neurons with non-neural cells generating a neuronal-inflammation state.
In this years, the study of mutual communication between neurons and immune cells was performed through a multidisciplinary project network with scientists from the Department of Neurobiology SISSA of Trieste (Italy), Dr . A. van den Maagdenberg and Dr. M. Ferrari from the Medical Center of the University of Leiden (Holland) and prof. Maria Pia Abbracchio from University of Milan (Italy). We used a transgenic animal model of hemiplegic migraine patronymic type 1, to demonstrate a new abnormal mechanism in the trigeminal ganglion mouse model that presumably will occur also in migraine patients. This work has also lead us to study regulation of pain ATP receptors in a neuro-inflammatory state.
Significance for the country
Chronic pain is a condition that affects significantly the quality of life of many patients for the lack of effective drugs. A better understanding of basic molecular mechanisms of chronic pain transition, is necessary to achieve progress in this area and generate new pharmacological solutions through translational events.
This project allowed to expand knowledge in the field in Slovenia, through the active involvement of several slovenian graduate and ungraduate students enrolled at University of Nova Gorica. The results and the achievements of these years have been selected for contribution within different dissemination and scientific events in Nova Gorica and in Ljubljana and abroad, contribuing to enlarge the reputation of local scientific community. Finally, also this project contributed to startup the new laboratories of the Center for biomedical sciences and engineering at University of Nova Gorica where further explore pain studies, important element of aging research.
Most important scientific results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si
