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Projects / Programmes source: ARIS

Zaščitni pleiotropni učinki nizkih odmerkov zaviralcev sistema renin-angiotenzin in statinov pri zdravi populaciji srednjih let (Slovene)

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Researchers (30)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18392  Meaz Agič    Technical associate  2009 - 2012 
2.  33910  Mateja Benčina Pirnat    Technical associate  2011 
3.  07630  PhD Aleš Blinc  Cardiovascular system  Researcher  2010 - 2012  501 
4.  28718  PhD Vinko Boc  Medical sciences  Researcher  2009 - 2012  76 
5.  08799  Matija Cevc  Cardiovascular system  Researcher  2009 - 2012  138 
6.  15099  PhD Darko Černe  Pharmacy  Researcher  2011 - 2012  262 
7.  13310  PhD Gorazd Drevenšek  Neurobiology  Researcher  2009 - 2012  330 
8.  22347  PhD Barbara Eržen  Cardiovascular system  Researcher  2009 - 2012  75 
9.  33060  Adrijana Gašparović    Technical associate  2011 
10.  17937  Matjaž Hrovat    Technical associate  2009 - 2012 
11.  25780  PhD Samo Hudoklin  Neurobiology  Researcher  2010  111 
12.  30830  PhD Mateja Kaja Ježovnik  Medical sciences  Junior researcher  2009  181 
13.  24467  PhD Borut Jug  Cardiovascular system  Researcher  2010 - 2012  312 
14.  15169  PhD Damijana Mojca Jurič  Neurobiology  Researcher  2009 - 2012  105 
15.  27741  PhD Simona Jurković Mlakar  Pharmacy  Researcher  2011  85 
16.  24835  Barbara Krevel  Cardiovascular system  Researcher  2009 - 2012  78 
17.  28865  PhD Mojca Lunder  Cardiovascular system  Junior researcher in economics  2009 - 2011  145 
18.  12189  PhD Janja Marc  Metabolic and hormonal disorders  Researcher  2009  717 
19.  27609  PhD Tina Mele  Control and care of the environment  Junior researcher  2009 - 2012  16 
20.  31213  Jovanka Mohar    Technical associate  2011 - 2012 
21.  17938  Petra Ponebšek    Technical associate  2009 - 2012 
22.  17932  Sonja Rozman    Technical associate  2009 - 2012 
23.  27822  Špela Sprogar  Stomatology  Researcher  2009 - 2012  42 
24.  08094  PhD Mirza Šabovič  Cardiovascular system  Head  2009 - 2012  424 
25.  06010  PhD Matjaž Šinkovec  Cardiovascular system  Researcher  2009 - 2012  261 
26.  29982  PhD Alenka Šmid  Pharmacy  Researcher  2009  124 
27.  25495  PhD Zoran Trošt  Metabolic and hormonal disorders  Junior researcher  2009  30 
28.  17941  Vesna Vidergar Ivanić    Technical associate  2009 - 2012 
29.  32807  PhD Peter Vrtačnik  Pharmacy  Junior researcher  2010 - 2012  18 
30.  29416  PhD Lovro Žiberna  Neurobiology  Junior researcher  2009 - 2011  249 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,929 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,724 
3.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,414 
Significance for science
The incidence of cardiovascular diseases is, despite of current therapeutic approaches, still rising in Western world and also in Slovenia. Therefore, new approaches for early prevention of these diseases, with the goal of prevention and treatment or postponing the onset of clinical signs of diseases to later life cycles, open new possibilities for better medical treatment and contribute to improving the quality of life. The content of this project represents a new, innovative idea for prevention and treatment of cardiovascular diseases. Globally, the content of the project for the first time represents the investigation of subtherapeutic doses of statins and renin-angiotensin blockers on the morphological and functional arterial wall changes, which are characteristic for the vascular aging. Models used for the study are suitable for monitoring early functional and morphologic changes that are clinically still silent. The research findings will also contribute to a better understanding of the concept of cardiovascular disease progression and will be the basis for the development of doctrine for their prevention.
Significance for the country
In Slovenia are currently in clinical practice introduced ultrasound methods to assign morphological characteristics of arteries. The ultrasound methods used in this study, in Slovenia has not been implemented yet, currently are also being introduced in the major world centers. So the methods represent a novelty in Slovenia as well as globally. These methods enable us to find early functional arterial wall changes that progressively lead to morphological ones with ageing. The content of the project is designed to be coordinated with the development policy of Slovenia in the field of health of citizens. The interaction of the results from preclinical and clinical research will allow better and faster transfer of knowledge into clinical practice, which in turn will lead to early inhibition and prevention of cardiovascular and degenerative diseases, and more effective therapy. Improving the health of the population is particularly important in the aging population, such as Slovenian and also European population is becoming. New approaches and improvement of the health status in terms of early treatment and prevention of these diseases with sub-therapeutic doses of drugs will lower the costs of the treatments and also the pressure on health care. Health status of the employed population will also be improved, which means greater performance and better professional development. Reducing the absence from work due to health problems is clearly an objective of Slovenia. The results of the study are applicative.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2010, 2011, final report, complete report on dLib.si
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