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Projects / Programmes source: ARIS

Uporaba izražanja izbranih genov kot novih potencialnih označevalcev pri diagnostiki in prognozi raka prostate (Slovene)

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Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (12)
no. Code Name and surname Research area Role Period No. of publications
1.  20403  PhD Dejan Bratuš  Oncology  Researcher  2010 - 2012  276 
2.  31203  Andrej Grajn  Oncology  Researcher  2009  7 
3.  19105  PhD Tine Hajdinjak  Oncology  Researcher  2009 - 2010  121 
4.  26256  Gregor Hlebič  Oncology  Researcher  2010 - 2012  83 
5.  30250  PhD Lidija Kocbek Šaherl  Medical sciences  Researcher  2009  49 
6.  13343  PhD Nadja Kokalj Vokač  Oncology  Head  2009 - 2012  448 
7.  30807  PhD Mihael Munda  Oncology  Researcher  2010 - 2012  52 
8.  31204  Marius K. Rebek  Oncology  Researcher  2009  33 
9.  20200  PhD Špela Stangler Herodež  Oncology  Researcher  2009 - 2012  241 
10.  31202  Jana Stanonik Godina  Oncology  Researcher  2009  14 
11.  07798  PhD Draga Štiblar Martinčič  Oncology  Researcher  2009 - 2012  161 
12.  18205  PhD Boris Zagradišnik  Oncology  Researcher  2009 - 2012  259 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  22,762 
2.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,526 
Significance for science
The research project yielded interesting results which allow to draw certain conclusions about a possible role of selected oncogenes SPINK1, GOLM1, IDH1, NEDD9, CPE, KRAS, IDH2, ADAMTS8, ADAMTS15 and EGFR in the development of prostate cancer at the time of first diagnosis. These genes appear not to be significantly involved. The featured genes are all known to be involved in different aspects of malignant transformation process. The analysis was performed on urin samples from patients with first diagnosis of prostate cancer and in majority of cases low malignant tumors were present. Although some high malignant prostate cancers were included a significant involvement of these genes was not observed. Also a small samples size of aggressive tumors does not allow to exclude a possible role for these genes in aggressive prostate cancer as it does for indolent prostate cancer cases. The results also do not identify the selected genes to be possible markers for hidden potential for aggressive growth in what appear to be prostate cancer of low malignancy at first diagnosis but can get converted to an aggressive form of prostate cancer. In addition typical mutation which are characteristic for the tyrosine kinase region of the EGFR gene were also absent from all analyzed prostate cancer cases. Consequently this type of genetic mutation may only occur in later stages or more advanced cancers. In contrast gene PCA3 was shown to be a significant biomarker for the prostate cancer in this research project and this finding may further exclude the selected genes to be good candidates for biomarkers specific for prostate cancer at the first diagnosis.
Significance for the country
This research project succeeded in establishing analytical capabilities for the detection of prostate cancer specific biomarkers. Expression analysis of the PCA3 gen showed that this gene has to be an important determinant for prostate cancer. Thus routine analysis of the PCA3 gene expression can be introduced in daily medical care for prostate cancer patients. Because of the aging of the population an increasing incidence of prostate cancer is expected and access to advanced testing procedures may be of paramount importance in order to ensure adequate treatment. A specific property of prostate cancer is that few aggressive cases are present inside a large cohort of mostly indolent case. Their timely recognition is a desirable goal which is hoped to be achieved with the development of novel disease specific biomarkers. The analysis did not provide evidence for significant involvement of selected genes in prostate cancer pathogenesis apart from the PCA3 gene. However the established analytical protocol offers a way of analyzing and discovering new biomarker of inters for prostate cancer. It is also important to stress our successful implementation of first voided urine as a source of prostate cancer cells for expression analysis. Therefore this research project represents a contribution to a never ending quest for state of the art management of prostate cancer in Slovenia.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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