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Projects / Programmes source: ARIS

Aktivacija imunskega odziva z naravnimi in sintetičnimi nanodelci (Slovene)

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Research activity

Code Science Field Subfield
7.00.00  Interdisciplinary research     
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (1)
no. Code Name and surname Research area Role Period No. of publications
1.  23563  PhD Iva Hafner Bratkovič  Neurobiology  Head  2009 - 2011  211 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,007 
Significance for science
Intracellular innate immunity receptors, especially NLRP3, are gaining importance due to their involvement in host pathogen response and in variety of common human pathological conditions, which is also acknowledged by most recent increase of publications in top impact journals, such as Science, Nature and Molecular Cell. Yet, the mechanism of NLRP3 activation has not been explained satisfactorily. The key goal of our research was to investigate and clarify the structural requirements for the activation of inflammasome. Using the same monomer (PrP) we prepared and characterized different supramolecular forms – from monomeric to unordered and ordered aggregates of various size and described the characteristics of NLRP3 inflammasome activators. Our interdisciplinary approach combining the expertise form structural and cell biology as well as material science represents innovative and original contribution in these very competitive disciplines.
Significance for the country
The interdisciplinary nature of the project opens new possibilities for international cooperation with researchers with whom we already collaborated e.g. within European projects and bilateral projects as well with new collaborators. Our department made some important contributions to the field of innate immunity, particularly in connection to membrane Toll-like receptors. This project is expanding the research of innate immunity towards defining the mechanisms of intracellular receptors.
Most important scientific results Annual report 2009, 2010, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, final report, complete report on dLib.si
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