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Projects / Programmes source: ARIS

SYNTOLL - Re-inženiring signalnega omrežja sesalske celice (Slovene)

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Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
1.07  Natural Sciences  Other natural sciences 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publications
1.  29065  Matevž Avbelj  Biotechnology  Technical associate  2010 - 2011  7 
2.  33301  Tibor Doles  Biochemistry and molecular biology  Technical associate  2013  41 
3.  28558  PhD Jernej Gašperšič  Biochemistry and molecular biology  Researcher  2010  62 
4.  24348  PhD Neža Grgurevič  Veterinarian medicine  Junior researcher  2010  58 
5.  23563  PhD Iva Hafner Bratkovič  Neurobiology  Researcher  2011 - 2013  210 
6.  10412  PhD Simon Horvat  Biotechnical sciences  Researcher  2010 - 2013  561 
7.  28971  Ana Jakopič    Technical associate  2010  14 
8.  06628  PhD Roman Jerala  Biochemistry and molecular biology  Head  2010 - 2013  1,190 
9.  31854  PhD Tomaž Koprivnjak  Biotechnology  Researcher  2010 - 2011  26 
10.  34069  PhD Duško Lainšček  Biotechnology  Junior researcher  2011 - 2013  148 
11.  32984  PhD Jan Lonzarić  Biochemistry and molecular biology  Technical associate  2010 - 2013  46 
12.  17917  PhD Andreja Majerle  Biotechnology  Researcher  2010 - 2013  92 
13.  21426  PhD Mateja Manček Keber  Pharmacy  Researcher  2011 - 2013  159 
14.  26500  PhD Nina Pirher  Biotechnology  Researcher  2010 - 2013  42 
15.  27547  PhD Zala Prevoršek  Animal production  Researcher  2010  42 
16.  25437  PhD Mateja Zorko Kern  Pharmacy  Researcher  2012 - 2013  40 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,982 
Significance for science
Discovery of new mechanisms of inhibition of TLR and their improvement is important for understanding the molecular mechanisms of cell signaling . The discovery of new details in the mechanism of cell signaling through TLR receptors and MyD88 adapter is important for understanding the function of innate immunity. Based of the detection of the impact of the INT domain, we can explain the inhibition of Myd88S alternative transcript. Discovery of the action of dimeric TIR domains allows to improve inhibition of the TLR signaling and contributes to the understanding of interactions between the TIR domains of proteins of the TLR signaling pathway, which is important for a number of inflammatory diseases, such as infections or chronic inflammatory diseases. Both types of inhibition are potentially interesting for therapeutic inhibition of inflammatory diseases. The project introduced the principles of synthetic biology in the manipulation of the immune response which is expected to provide innovative approaches to the treatment of an immune response, particularly inflammation. Of particular importance to science is the discovery of a modular implementation of DNA binding proteins for preparation orthogonal genetic NOR gate.
Significance for the country
Inflammation is associated with almost all diseases, from microbial infections to chronic inflammatory diseases such as atherosclerosis, arthritis and cancer. New approaches to the treatment of inflammatory diseases could be important for improving health, and on the other hand, also for the development of biotechnology in Slovenia. The project has direct relevance to the society through the achievement of high level of science and training of highly qualified personnel which represents the best investment for the economic development. The development of inventive methods of synthetic immunology is from an economic standpoint a perfect base for business initiatives. We filed patent applications for three inventions, which may allowing either their licensing or starting a company to commercially exploit the results. The project involved young researchers and graduate students and thus contributed to increasing the number of skillfully trained and innovative personnel in the field of biotechnology.
Most important scientific results Annual report 2010, 2011, 2012, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2010, 2011, 2012, final report, complete report on dLib.si
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