Projects / Programmes
Molecular genetics in biomedical research
| Code |
Science |
Field |
Subfield |
| 1.05.00 |
Natural sciences and mathematics |
Biochemistry and molecular biology |
|
| Code |
Science |
Field |
| B220 |
Biomedical sciences |
Genetics, cytogenetics |
| T490 |
Technological sciences |
Biotechnology |
r-DNA, gene technology, gene cloning, genome, gene expression; molecular genetics, genetic diseases, gene diagnostics, gene therapy, oncogenes, tumor suppressor genes, mismatch repair genes; cytochrome P450, steroid hydroxylation
Researchers (6)
Organisations (1)
Abstract
Project MOLECULAR GENETICS IN BIOMEDICAL RESEARCH is composed by two project subgroups: A/ Investigation of steroid metabolism with recombinant DNA technology; B/ Recombinant DNA technology in research on monogenic diseases and gene malformations.
The aim of the project subgroup A is instalation of principles and methods for cloning of microbial genes encoding enzymes for biotechnological (pharmacological) relevant steroid bioconversions, and for further experiments on co-expression of the different heterologous steroid-bioconverting enzymes in the same host organism. In adition, biochemistry and molecular biology of the microorganisms harbouring the genes to be cloned, is studied.
The project subgroup B is oriented to the use of r-DNA methods in searching for disease genes and looking for mutations and/or gene variations in order to understand the mechanisms of different genetic diseases and malformations. Results are available for the clinical and antinatal DNA-based diagnostics of some genetic diseases/malformations in Slovenia.
Both sub-projects are linked by introducing and using of the recent r-DNA and molecular genetic methods. Additional common point is also steroid metabolism, as investigation of genetic diseases resulting from impaired steroid metabolism represents a great part of the sub-project B.
