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Synthesis of nonnatural oligonucleotides for recognition of gc base pairs by triple helix formation

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Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
Keywords
NUCLEOSIDES, OLIGONUCLEOTIDES, TRIPLE HELIX, ANTICANCER
Evaluation (metodology)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
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Organisations (1) , Researchers (2)
0104  National Institute of Chemistry
no. Code Name and surname Research area Role Period No. of publications
1.  01914  PhD Jože Kobe  Chemistry  Head  1997 - 1999  197 
2.  01852  PhD Marija Prhavc  Chemistry  Researcher  1998 - 1999  24 
Abstract
The synthesis of nonnatural oligonucleotides aiming for ''''antisense'''' and ''''antigene'''' strategy is proposed. In short oligonucleotides guanine moieties will be substituted by synthetic analogs with modified bases or sugars or both. The design is aimed to suppress the obstacles like degradation and permeability. These features will be correlated to the structural parameters.
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