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Projects / Programmes source: ARIS

Sinteza, pretvorbe in uporaba nekaterih potencialnih biološko pomembnih spojin (Slovene)

Research activity

Code Science Field Subfield
1.04.04  Natural sciences and mathematics  Chemistry  Organic chemistry 

Code Science Field
P003  Natural sciences and mathematics  Chemistry 
P390  Natural sciences and mathematics  Organic chemistry 
Keywords
Tandem cyclization; a-heteroarylglycines; spiroheterocycles; azoloazines; indoles; diazene-carboxamides; selective oxidations; thiols; glutathione; cyclic voltammetry; electrophilic amination; pyrimidine N-oxides; positron emission tomography; fluorescent probes.
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  17138  Zdenka Kadunc    Researcher  1996 - 2001 
2.  17139  Marjeta Katarin Kastelic    Researcher  1996 - 2001 
3.  11398  PhD Vladimir Kepe  Neurobiology  Researcher  1996 - 2001  43 
4.  03904  PhD Marijan Kočevar  Chemistry  Researcher  1996 - 2001  577 
5.  11881  PhD Patrik Kolar  Chemistry  Researcher  1999 - 2001  96 
6.  13822  PhD Janez Košmrlj  Chemistry  Researcher  1999 - 2001  539 
7.  17140  Tončka Kozamernik-Hudeček    Researcher  1999 - 2001 
8.  03374  PhD Ivan Leban  Chemistry  Researcher  1996 - 2001  542 
9.  05044  PhD Andrej Petrič  Chemistry  Researcher  1999 - 2001  217 
10.  02310  PhD Slovenko Polanc  Chemistry  Head  1998 - 2001  550 
11.  19527  Irena Povalej    Researcher  1999 - 2001 
12.  18423  PhD Bogdan Štefane  Chemistry  Researcher  1996 - 2001  407 
13.  17142  Tatjana Toporiš Stipanovič    Researcher  1999 - 2001 
14.  02314  PhD Bojan Verček  Chemistry  Researcher  1999 - 2001  151 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,454 
Abstract
Synthetic approach towards new heterocycles as starting materials with potential pharma-cological properties represents the search for the model compounds as precursors for biologically active compounds. Our efforts are devoted to: (i) The synthesis of heterocycles with incorporated amino acid unit; studies involve new synthetic routes to heterocyclic systems via tandem cyclization, and an application of a-heteroarylglycines for the preparation of azolo-azines. Investigations also include new spiroheterocyclic systems and several reduced indoles. (ii) Transformations of a variety of new 1,4-disubstituted semicarbazides in order to obtain to the corresponding diazenecarboxamides. The latter type of compounds are applied as selective oxidants of thiols to disulfides and are studied by cyclic voltammetry to evaluate their oxidative potential. Several diazenecarboxamides are examined as new reagents for the electrophilic amination of the appripriate arenes and other compounds. In some cases the electrophilic amination involves not only an intermolecular attack but intramolecular conversion within the diazene molecule as well. Depending on the reactivity of both partners one can predict the outcome of the reaction. (iii) Our continuous interest in searching for new biologically active molecules results in the approach to pyrimidine N-oxides as several N-oxides were shown to possess hypotensive activity in man. I addition, they have alredy been described as inhibitors of lysyl hydroxylase, dihydrofolate reductase and to prevent of loss of hair as well as inducing and stimulating its growth. Our new and general method for the preparation of pyrimidine N-oxides involves the treatment of the appropriate caboxamide oximes with 1,3-dicarbonyl compounds or their equivalents under acidic conditions. (iv) Investigations towards new probes for positron emission tomography of dopamine D2 system which could provide means to measure rates of biological processes.
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