Projects / Programmes source: ARIS

Aminokisline kot gradniki v organski sintezi (Slovene)

Research activity

Code Science Field Subfield
1.04.04  Natural sciences and mathematics  Chemistry  Organic chemistry 

Code Science Field
P003  Natural sciences and mathematics  Chemistry 
P390  Natural sciences and mathematics  Organic chemistry 
Amino acids, unsaturated; catalysis, homogeneous or heterogeneous; asymmetric synthesis; hydrogenation; oxygenation; high-pressure research; heterocycles; pyrons; benzopyrans; benzofurans; 5(4H)-oxazolones; dioxiranes.
Evaluation (rules)
source: COBISS
Researchers (10)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  08385  PhD Janez Cerkovnik  Chemistry  Researcher  2000 - 2001  178 
2.  21173  PhD Marjan Ješelnik  Chemistry  Researcher  1996 - 2001  30 
3.  17138  Zdenka Kadunc    Researcher  2000 - 2001 
4.  11398  PhD Vladimir Kepe  Neurobiology  Researcher  1996 - 2001  43 
5.  03904  PhD Marijan Kočevar  Chemistry  Head  1999 - 2001  578 
6.  20063  PhD Krištof Kranjc  Chemistry  Researcher  1996 - 2001  270 
7.  03374  PhD Ivan Leban  Chemistry  Researcher  1996 - 2001  542 
8.  05044  PhD Andrej Petrič  Chemistry  Researcher  1998 - 2001  218 
9.  02310  PhD Slovenko Polanc  Chemistry  Researcher  1996 - 2001  551 
10.  19405  PhD Franc Požgan  Chemistry  Researcher  1996 - 2001  383 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,814 
We investigate novel synthetic approaches to potentially biologically active com--pounds containing amino acid units in their structure. The emphasis is given on unsatu-rated dehydroamino acid derivatives, elucidation of their structure and further selective or stereo-selective conversions: reductions, oxidations, transformations into various heterocyclic systems, etc. We are also investigating structure – activity relationship and using mod-ern methods for the design of biologically active compounds, including molecular model-ling by the application of experimentally obtained data on the basis of NMR spectra. In particular, we are interested in selective transformations into (Z)- and (E)-derivatives of di-de-hydro-amino acids, possibility of their interconversion and their further transformations. Recently, such compounds were extensively used as excellent synthons for enantioselective homogenous catalytic hydrogenation as well as to find the best catalysts for such conver-sions. We are also planing to study stereoselective reduction of prochiral ketones by the appli-ca-tion of various reducing agents, such as for example optically active complexes of transition metals, homogeneous or heterogeneous catalytic hydrogenation. On the other hand, we plan to investigate se-lec-tive or stereoselective oxidations of unsaturated organic compounds with ecologically pure oxidants, such as peroxides, for example hydrogen peroxide or cyclic dimethyldioxirane. This field of investigation belongs to the preferential investigation in COST D12 program within EU (Organic Transformations: Selective Processes and Asymmetric Catalysis). We are also planing to start the research at the high pressures (č15 kbar), at which some reactions (cycloadditions, substitutions, etc.) take place easier than at the normal condi-tions. Here, it is often easily to study mechanisms, due to the easier capture of intermediates than at the normal pressure.
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