Projects / Programmes
Aminokisline kot gradniki v organski sintezi (Slovene)
| Code |
Science |
Field |
Subfield |
| 1.04.04 |
Natural sciences and mathematics |
Chemistry |
Organic chemistry |
| Code |
Science |
Field |
| P003 |
Natural sciences and mathematics |
Chemistry |
| P390 |
Natural sciences and mathematics |
Organic chemistry |
Amino acids, unsaturated; catalysis, homogeneous or heterogeneous; asymmetric synthesis; hydrogenation; oxygenation; high-pressure research; heterocycles; pyrons; benzopyrans; benzofurans; 5(4H)-oxazolones; dioxiranes.
Researchers (10)
Organisations (1)
Abstract
We investigate novel synthetic approaches to potentially biologically active com--pounds containing amino acid units in their structure. The emphasis is given on unsatu-rated dehydroamino acid derivatives, elucidation of their structure and further selective or stereo-selective conversions: reductions, oxidations, transformations into various heterocyclic systems, etc. We are also investigating structure – activity relationship and using mod-ern methods for the design of biologically active compounds, including molecular model-ling by the application of experimentally obtained data on the basis of NMR spectra.
In particular, we are interested in selective transformations into (Z)- and (E)-derivatives of di-de-hydro-amino acids, possibility of their interconversion and their further transformations. Recently, such compounds were extensively used as excellent synthons for enantioselective homogenous catalytic hydrogenation as well as to find the best catalysts for such conver-sions. We are also planing to study stereoselective reduction of prochiral ketones by the appli-ca-tion of various reducing agents, such as for example optically active complexes of transition metals, homogeneous or heterogeneous catalytic hydrogenation. On the other hand, we plan to investigate se-lec-tive or stereoselective oxidations of unsaturated organic compounds with ecologically pure oxidants, such as peroxides, for example hydrogen peroxide or cyclic dimethyldioxirane. This field of investigation belongs to the preferential investigation in COST D12 program within EU (Organic Transformations: Selective Processes and Asymmetric Catalysis).
We are also planing to start the research at the high pressures (č15 kbar), at which some reactions (cycloadditions, substitutions, etc.) take place easier than at the normal condi-tions. Here, it is often easily to study mechanisms, due to the easier capture of intermediates than at the normal pressure.
