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Projects / Programmes source: ARIS

Synthesis of potentially active species deriving from alpha - halopryruvamides

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Research activity

Code Science Field Subfield
1.04.04  Natural sciences and mathematics  Chemistry  Organic chemistry 

Code Science Field
P390  Natural sciences and mathematics  Organic chemistry 
Keywords
oksiranes, alpha-halopyruvamides, alpha-keto beta-laktames, imidazo tiazoles, organic synthesis, identfication
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publications
1.  04623  Zvonka Blažič  Textile and leather  Researcher  1998 - 2001  0 
2.  01407  PhD Aleksandra Lobnik  Textile and leather  Researcher  1999 - 2001  0 
3.  02223  PhD Alenka Majcen Le Marechal  Chemistry  Head  1999 - 2001  0 
4.  17581  Ernest Šimon    Researcher  1998 - 2001  0 
5.  06385  PhD Bojana Vončina  Materials science and technology  Researcher  1999 - 2001  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  2 
Abstract
We will try to develop new synthetic methods for the preparation of interesting potentially bilogically active species. Alpha-Halopyruvamides as starting compounds belong to alpha-haloketons, interesting compounds in organic synthesis. They will be prepared form geminal dicyano oxiranes through cyanohydrin intermediates, transformed thermaly to alpha-halopyruvamides. We wil carry out reactions with different binucleophiles on alpha-halopyruvamides. We will also try to transform the latter compounds into alpha-keto beta-laktames. The reactional mechanism will be studied and new products structurally characterized. Screening of the bilogical activity of isolated compounds will be realized. We expect from isolated structurally different compounds to be stabel enough for biological screening in the direction of potential citostatic and anti-inflammatory properties.
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