Filters
cris logo
-
New search Filters
Select from list
Displayed from Show more
You have reached the maximum number of displayed search results.
All results displayed
No results are available for the search performed
Displayed from
You have reached the maximum number of displayed search results.
All results displayed
Loading results
Obtaining statistical data

Projects / Programmes source: ARIS

Biologically active Pt-complexes

Edit
Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P360  Natural sciences and mathematics  Inorganic chemistry 
B190  Biomedical sciences  Clinical chemistry 
Keywords
platinum, complexes, nucleozides, amino acids, X-ray diffraction, HPLC, NMR, biological activity
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (2)
no. Code Name and surname Research area Role Period No. of publications
1.  00190  PhD Jurij Brenčič  Chemistry  Researcher  1998 - 2001  241 
2.  03440  PhD Nataša Bukovec  Chemistry  Head  1998 - 2001  351 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,099 
Abstract
Our proposal is to combine in one drug the antiviral activity of nucleotide analogues with ability of cisplatin type complexes to transport ligands to target sites and render them resistent to enzymatic degradation. We will prepare and structurally characterize Pt(II) coordination compounds with acyclovir (acv, 9-Š(2-hydroxyethoxy)methylĆguanine) and Pt(II) coordination compounds with acv and amino acids. Besides cisplatin other Pt(II) precursors will be used also. Solid phases will be structurally characterized by X-ray diffraction. The speciation and structural relations in aqueous solutions will be studied by HPLC and NMR.
Confirmation required
Views history
Favourite